Surveillance study for creating the national clinical database relating to ECG-gated myocardial perfusion SPECT of asymptomatic ischemic heart disease in patients with type-2 diabetes mellitus: J-ACCESS 2 study design

Hideo Kusuoka, Yoshimitsu Yamasaki, Tohru Izumi, Atsunori Kashiwagi, Ryuzo Kawamori, Kazuaki Shimamoto, Nobuhiro Yamada, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Objective: Diabetes mellitus is an independent risk factor for acute myocardial infarction. Thus, a surveillance study was conducted as part of studies to create a national database related to electrocardiogram (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT) of ischemic heart disease. Methods: Single-photon emission computed tomography was conducted in patients with type 2 diabetes mellitus and their prognoses will be followed for 3 years, stratified by patients' clinical background and SPECT findings. Results: A total of 513 patients from 50 institutions were enrolled in this study, 297 of whom were men (age 66.2 ± 0.4 years, mean ± SEM) and 261 women (age 67.8 ± 0.5 years). They have a history of retinopathy (25.3%), neuropathy (19.9%), cerebrovascular disorder, chronic obstructive pulmonary disease, and photocoagulation. Major risk factors for present disease were hypertension (82.3%) and hyperlipidemia (79.7%). In 244 patients (129 men and 115 women), body mass index (BMI) was 25 or more. Fifty-two of them (10.1%) underwent coronary angiography; of these, 26 (50.0%) had no coronary artery lesions with 75% or more stenosis, and only 1 (1.9%) had a left main trunk with 50% or more stenosis. An overwhelming majority of patients (94.3%) underwent SPECT imaging by a 1-day stress-followed-by-rest procedure. Stress procedure was exercise in most (70.8%) patients, followed by dipyridamole infusion in 14.6%, adenosine infusion in 6.6%, and adenosine triphosphate infusion in 5.7%. Endpoint of stress examination was most often fatigue in lower limbs (40.7%), followed by completion of pharmacological stress protocol (28.7%), and achievement of target heart rate (26.3%). The largest number of patients (198, 38.6%) received 99mTc-tetrofosmin at an initial dosage of 200-300 MBq (mean 331 ± 3 MBq) followed by a second dosage of 700-800 MBq (mean 748 ± 8 MBq). Among them, 491 (95.7%) received some kind of therapeutic drug: hypoglycemic drugs were used by the largest number (83.2%), followed by hypotensive (66.7%), hypolipidemic (40.7%), and antiplatelet drugs (27.7%), vasodilators (5.5%), and antioxidants and others (2.3%). Conclusions: This study was designed to clarify the correlation between coronary artery disease and diabetes mellitus as its risk factor based on the clinical and imaging findings. Patient enrollment was closed on September 30, 2005, and follow-up is now under way.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalAnnals of Nuclear Medicine
Volume22
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Single-Photon Emission-Computed Tomography
Type 2 Diabetes Mellitus
Myocardial Ischemia
Electrocardiography
Perfusion
Databases
Diabetes Mellitus
Pathologic Constriction
Hypolipidemic Agents
Cerebrovascular Disorders
Dipyridamole
Light Coagulation
Platelet Aggregation Inhibitors
Hyperlipidemias
Coronary Angiography
Vasodilator Agents
Hypoglycemic Agents
Adenosine
Chronic Obstructive Pulmonary Disease
Fatigue

Keywords

  • Tc-tetrofosmin
  • Diabetes mellitus
  • ECG-gated myocardial perfusion SPECT
  • Ischemic heart disease
  • Prognosis prediction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Surveillance study for creating the national clinical database relating to ECG-gated myocardial perfusion SPECT of asymptomatic ischemic heart disease in patients with type-2 diabetes mellitus : J-ACCESS 2 study design. / Kusuoka, Hideo; Yamasaki, Yoshimitsu; Izumi, Tohru; Kashiwagi, Atsunori; Kawamori, Ryuzo; Shimamoto, Kazuaki; Yamada, Nobuhiro; Nishimura, Tsunehiko.

In: Annals of Nuclear Medicine, Vol. 22, No. 1, 01.2008, p. 13-21.

Research output: Contribution to journalArticle

Kusuoka, Hideo ; Yamasaki, Yoshimitsu ; Izumi, Tohru ; Kashiwagi, Atsunori ; Kawamori, Ryuzo ; Shimamoto, Kazuaki ; Yamada, Nobuhiro ; Nishimura, Tsunehiko. / Surveillance study for creating the national clinical database relating to ECG-gated myocardial perfusion SPECT of asymptomatic ischemic heart disease in patients with type-2 diabetes mellitus : J-ACCESS 2 study design. In: Annals of Nuclear Medicine. 2008 ; Vol. 22, No. 1. pp. 13-21.
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abstract = "Objective: Diabetes mellitus is an independent risk factor for acute myocardial infarction. Thus, a surveillance study was conducted as part of studies to create a national database related to electrocardiogram (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT) of ischemic heart disease. Methods: Single-photon emission computed tomography was conducted in patients with type 2 diabetes mellitus and their prognoses will be followed for 3 years, stratified by patients' clinical background and SPECT findings. Results: A total of 513 patients from 50 institutions were enrolled in this study, 297 of whom were men (age 66.2 ± 0.4 years, mean ± SEM) and 261 women (age 67.8 ± 0.5 years). They have a history of retinopathy (25.3{\%}), neuropathy (19.9{\%}), cerebrovascular disorder, chronic obstructive pulmonary disease, and photocoagulation. Major risk factors for present disease were hypertension (82.3{\%}) and hyperlipidemia (79.7{\%}). In 244 patients (129 men and 115 women), body mass index (BMI) was 25 or more. Fifty-two of them (10.1{\%}) underwent coronary angiography; of these, 26 (50.0{\%}) had no coronary artery lesions with 75{\%} or more stenosis, and only 1 (1.9{\%}) had a left main trunk with 50{\%} or more stenosis. An overwhelming majority of patients (94.3{\%}) underwent SPECT imaging by a 1-day stress-followed-by-rest procedure. Stress procedure was exercise in most (70.8{\%}) patients, followed by dipyridamole infusion in 14.6{\%}, adenosine infusion in 6.6{\%}, and adenosine triphosphate infusion in 5.7{\%}. Endpoint of stress examination was most often fatigue in lower limbs (40.7{\%}), followed by completion of pharmacological stress protocol (28.7{\%}), and achievement of target heart rate (26.3{\%}). The largest number of patients (198, 38.6{\%}) received 99mTc-tetrofosmin at an initial dosage of 200-300 MBq (mean 331 ± 3 MBq) followed by a second dosage of 700-800 MBq (mean 748 ± 8 MBq). Among them, 491 (95.7{\%}) received some kind of therapeutic drug: hypoglycemic drugs were used by the largest number (83.2{\%}), followed by hypotensive (66.7{\%}), hypolipidemic (40.7{\%}), and antiplatelet drugs (27.7{\%}), vasodilators (5.5{\%}), and antioxidants and others (2.3{\%}). Conclusions: This study was designed to clarify the correlation between coronary artery disease and diabetes mellitus as its risk factor based on the clinical and imaging findings. Patient enrollment was closed on September 30, 2005, and follow-up is now under way.",
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T1 - Surveillance study for creating the national clinical database relating to ECG-gated myocardial perfusion SPECT of asymptomatic ischemic heart disease in patients with type-2 diabetes mellitus

T2 - J-ACCESS 2 study design

AU - Kusuoka, Hideo

AU - Yamasaki, Yoshimitsu

AU - Izumi, Tohru

AU - Kashiwagi, Atsunori

AU - Kawamori, Ryuzo

AU - Shimamoto, Kazuaki

AU - Yamada, Nobuhiro

AU - Nishimura, Tsunehiko

PY - 2008/1

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N2 - Objective: Diabetes mellitus is an independent risk factor for acute myocardial infarction. Thus, a surveillance study was conducted as part of studies to create a national database related to electrocardiogram (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT) of ischemic heart disease. Methods: Single-photon emission computed tomography was conducted in patients with type 2 diabetes mellitus and their prognoses will be followed for 3 years, stratified by patients' clinical background and SPECT findings. Results: A total of 513 patients from 50 institutions were enrolled in this study, 297 of whom were men (age 66.2 ± 0.4 years, mean ± SEM) and 261 women (age 67.8 ± 0.5 years). They have a history of retinopathy (25.3%), neuropathy (19.9%), cerebrovascular disorder, chronic obstructive pulmonary disease, and photocoagulation. Major risk factors for present disease were hypertension (82.3%) and hyperlipidemia (79.7%). In 244 patients (129 men and 115 women), body mass index (BMI) was 25 or more. Fifty-two of them (10.1%) underwent coronary angiography; of these, 26 (50.0%) had no coronary artery lesions with 75% or more stenosis, and only 1 (1.9%) had a left main trunk with 50% or more stenosis. An overwhelming majority of patients (94.3%) underwent SPECT imaging by a 1-day stress-followed-by-rest procedure. Stress procedure was exercise in most (70.8%) patients, followed by dipyridamole infusion in 14.6%, adenosine infusion in 6.6%, and adenosine triphosphate infusion in 5.7%. Endpoint of stress examination was most often fatigue in lower limbs (40.7%), followed by completion of pharmacological stress protocol (28.7%), and achievement of target heart rate (26.3%). The largest number of patients (198, 38.6%) received 99mTc-tetrofosmin at an initial dosage of 200-300 MBq (mean 331 ± 3 MBq) followed by a second dosage of 700-800 MBq (mean 748 ± 8 MBq). Among them, 491 (95.7%) received some kind of therapeutic drug: hypoglycemic drugs were used by the largest number (83.2%), followed by hypotensive (66.7%), hypolipidemic (40.7%), and antiplatelet drugs (27.7%), vasodilators (5.5%), and antioxidants and others (2.3%). Conclusions: This study was designed to clarify the correlation between coronary artery disease and diabetes mellitus as its risk factor based on the clinical and imaging findings. Patient enrollment was closed on September 30, 2005, and follow-up is now under way.

AB - Objective: Diabetes mellitus is an independent risk factor for acute myocardial infarction. Thus, a surveillance study was conducted as part of studies to create a national database related to electrocardiogram (ECG)-gated myocardial perfusion single-photon emission computed tomography (SPECT) of ischemic heart disease. Methods: Single-photon emission computed tomography was conducted in patients with type 2 diabetes mellitus and their prognoses will be followed for 3 years, stratified by patients' clinical background and SPECT findings. Results: A total of 513 patients from 50 institutions were enrolled in this study, 297 of whom were men (age 66.2 ± 0.4 years, mean ± SEM) and 261 women (age 67.8 ± 0.5 years). They have a history of retinopathy (25.3%), neuropathy (19.9%), cerebrovascular disorder, chronic obstructive pulmonary disease, and photocoagulation. Major risk factors for present disease were hypertension (82.3%) and hyperlipidemia (79.7%). In 244 patients (129 men and 115 women), body mass index (BMI) was 25 or more. Fifty-two of them (10.1%) underwent coronary angiography; of these, 26 (50.0%) had no coronary artery lesions with 75% or more stenosis, and only 1 (1.9%) had a left main trunk with 50% or more stenosis. An overwhelming majority of patients (94.3%) underwent SPECT imaging by a 1-day stress-followed-by-rest procedure. Stress procedure was exercise in most (70.8%) patients, followed by dipyridamole infusion in 14.6%, adenosine infusion in 6.6%, and adenosine triphosphate infusion in 5.7%. Endpoint of stress examination was most often fatigue in lower limbs (40.7%), followed by completion of pharmacological stress protocol (28.7%), and achievement of target heart rate (26.3%). The largest number of patients (198, 38.6%) received 99mTc-tetrofosmin at an initial dosage of 200-300 MBq (mean 331 ± 3 MBq) followed by a second dosage of 700-800 MBq (mean 748 ± 8 MBq). Among them, 491 (95.7%) received some kind of therapeutic drug: hypoglycemic drugs were used by the largest number (83.2%), followed by hypotensive (66.7%), hypolipidemic (40.7%), and antiplatelet drugs (27.7%), vasodilators (5.5%), and antioxidants and others (2.3%). Conclusions: This study was designed to clarify the correlation between coronary artery disease and diabetes mellitus as its risk factor based on the clinical and imaging findings. Patient enrollment was closed on September 30, 2005, and follow-up is now under way.

KW - Tc-tetrofosmin

KW - Diabetes mellitus

KW - ECG-gated myocardial perfusion SPECT

KW - Ischemic heart disease

KW - Prognosis prediction

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