Surveillance for neoplasia in the pancreas

Kasper A. Overbeek, Djuna L. Cahen, Marcia Irene Canto, Marco J. Bruno

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Despite its low incidence in the general population, pancreatic cancer is one of the leading causes of cancer-related mortality. Survival greatly depends on operability, but most patients present with unresectable disease. Therefore, there is great interest in the early detection of pancreatic cancer and its precursor lesions by surveillance. Worldwide, several programs have been initiated for individuals at high risk for pancreatic cancer. Their first results suggest that surveillance in high-risk individuals is feasible, but their effectiveness in decreasing mortality remains to be proven. This review will discuss which individuals are eligible for surveillance, which lesions are aimed to be detected, and which surveillance modalities are being used in current clinical practice. Furthermore, it addresses the management of abnormalities found during surveillance and topics for future research.

Original languageEnglish (US)
Pages (from-to)971-986
Number of pages16
JournalBest Practice and Research: Clinical Gastroenterology
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2016

Keywords

  • Early detection of cancer
  • Genetic predisposition to disease
  • Hereditary
  • Neoplastic syndromes
  • Pancreatic cyst
  • Pancreatic neoplasms

ASJC Scopus subject areas

  • Gastroenterology

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