Surgically staged focal liver lesions

Accuracy and reproducibility of dual-phase helical CT for detection and characterization

Ihab R Kamel, Michael A. Choti, Karen M Horton, H. J V Braga, Bernard A. Birnbaum, Elliot K Fishman, Richard Thompson, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

PURPOSE: To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions. MATERIALS AND METHODS: Surgically and histopathologically proven liver lesions were evaluated by three experienced CT readers. These lesions were present in 77 patients who underwent dual-phase helical CT. Images were interpreted separately by the three blinded reviewers. Each lesion was graded on a nine-point scale of confidence, with 1 being definitely benign, 9 being definitely malignant, and 5 being indeterminate. The χ2 test was used to determine if the distribution of lesion classifications was different between readers. RESULTS: There was a total of 237 lesions: 73 were benign and 164 were malignant. Sensitivity for lesion detection was 69%, 70%, and 71% for the three reviewers, respectively. Specificity was 91%, 86%, and 90%, and the area under the curve for the alternative-free response receiver operating characteristic curve was 0.84, 0.83, and 0.85, respectively. The difference in the distributions of lesion classification between the three reviewers was not statistically significant (P = .67) as determined by χ2 analysis. CONCLUSION: Dual-phase CT has sensitivity of 69%-71% and high specificity (86%-91%) in enabling the detection and characterization of focal liver lesions. Interpretation is highly reproducible, as there is minimal variation between experienced reviewers.

Original languageEnglish (US)
Pages (from-to)752-757
Number of pages6
JournalRadiology
Volume227
Issue number3
DOIs
StatePublished - Jun 1 2003

Fingerprint

Spiral Computed Tomography
Liver
Tomography
ROC Curve
Area Under Curve

Keywords

  • Liver neoplasms, CT
  • Liver neoplasms, diagnosis
  • Liver neoplasms, metastases

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Surgically staged focal liver lesions : Accuracy and reproducibility of dual-phase helical CT for detection and characterization. / Kamel, Ihab R; Choti, Michael A.; Horton, Karen M; Braga, H. J V; Birnbaum, Bernard A.; Fishman, Elliot K; Thompson, Richard; Bluemke, David A.

In: Radiology, Vol. 227, No. 3, 01.06.2003, p. 752-757.

Research output: Contribution to journalArticle

@article{ee608389b8f2477f89e3cb16bbf5aa48,
title = "Surgically staged focal liver lesions: Accuracy and reproducibility of dual-phase helical CT for detection and characterization",
abstract = "PURPOSE: To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions. MATERIALS AND METHODS: Surgically and histopathologically proven liver lesions were evaluated by three experienced CT readers. These lesions were present in 77 patients who underwent dual-phase helical CT. Images were interpreted separately by the three blinded reviewers. Each lesion was graded on a nine-point scale of confidence, with 1 being definitely benign, 9 being definitely malignant, and 5 being indeterminate. The χ2 test was used to determine if the distribution of lesion classifications was different between readers. RESULTS: There was a total of 237 lesions: 73 were benign and 164 were malignant. Sensitivity for lesion detection was 69{\%}, 70{\%}, and 71{\%} for the three reviewers, respectively. Specificity was 91{\%}, 86{\%}, and 90{\%}, and the area under the curve for the alternative-free response receiver operating characteristic curve was 0.84, 0.83, and 0.85, respectively. The difference in the distributions of lesion classification between the three reviewers was not statistically significant (P = .67) as determined by χ2 analysis. CONCLUSION: Dual-phase CT has sensitivity of 69{\%}-71{\%} and high specificity (86{\%}-91{\%}) in enabling the detection and characterization of focal liver lesions. Interpretation is highly reproducible, as there is minimal variation between experienced reviewers.",
keywords = "Liver neoplasms, CT, Liver neoplasms, diagnosis, Liver neoplasms, metastases",
author = "Kamel, {Ihab R} and Choti, {Michael A.} and Horton, {Karen M} and Braga, {H. J V} and Birnbaum, {Bernard A.} and Fishman, {Elliot K} and Richard Thompson and Bluemke, {David A.}",
year = "2003",
month = "6",
day = "1",
doi = "10.1148/radiol.2273011768",
language = "English (US)",
volume = "227",
pages = "752--757",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

TY - JOUR

T1 - Surgically staged focal liver lesions

T2 - Accuracy and reproducibility of dual-phase helical CT for detection and characterization

AU - Kamel, Ihab R

AU - Choti, Michael A.

AU - Horton, Karen M

AU - Braga, H. J V

AU - Birnbaum, Bernard A.

AU - Fishman, Elliot K

AU - Thompson, Richard

AU - Bluemke, David A.

PY - 2003/6/1

Y1 - 2003/6/1

N2 - PURPOSE: To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions. MATERIALS AND METHODS: Surgically and histopathologically proven liver lesions were evaluated by three experienced CT readers. These lesions were present in 77 patients who underwent dual-phase helical CT. Images were interpreted separately by the three blinded reviewers. Each lesion was graded on a nine-point scale of confidence, with 1 being definitely benign, 9 being definitely malignant, and 5 being indeterminate. The χ2 test was used to determine if the distribution of lesion classifications was different between readers. RESULTS: There was a total of 237 lesions: 73 were benign and 164 were malignant. Sensitivity for lesion detection was 69%, 70%, and 71% for the three reviewers, respectively. Specificity was 91%, 86%, and 90%, and the area under the curve for the alternative-free response receiver operating characteristic curve was 0.84, 0.83, and 0.85, respectively. The difference in the distributions of lesion classification between the three reviewers was not statistically significant (P = .67) as determined by χ2 analysis. CONCLUSION: Dual-phase CT has sensitivity of 69%-71% and high specificity (86%-91%) in enabling the detection and characterization of focal liver lesions. Interpretation is highly reproducible, as there is minimal variation between experienced reviewers.

AB - PURPOSE: To assess the accuracy and reproducibility of dual-phase helical computed tomography (CT) in enabling preoperative detection and characterization of surgically staged focal liver lesions. MATERIALS AND METHODS: Surgically and histopathologically proven liver lesions were evaluated by three experienced CT readers. These lesions were present in 77 patients who underwent dual-phase helical CT. Images were interpreted separately by the three blinded reviewers. Each lesion was graded on a nine-point scale of confidence, with 1 being definitely benign, 9 being definitely malignant, and 5 being indeterminate. The χ2 test was used to determine if the distribution of lesion classifications was different between readers. RESULTS: There was a total of 237 lesions: 73 were benign and 164 were malignant. Sensitivity for lesion detection was 69%, 70%, and 71% for the three reviewers, respectively. Specificity was 91%, 86%, and 90%, and the area under the curve for the alternative-free response receiver operating characteristic curve was 0.84, 0.83, and 0.85, respectively. The difference in the distributions of lesion classification between the three reviewers was not statistically significant (P = .67) as determined by χ2 analysis. CONCLUSION: Dual-phase CT has sensitivity of 69%-71% and high specificity (86%-91%) in enabling the detection and characterization of focal liver lesions. Interpretation is highly reproducible, as there is minimal variation between experienced reviewers.

KW - Liver neoplasms, CT

KW - Liver neoplasms, diagnosis

KW - Liver neoplasms, metastases

UR - http://www.scopus.com/inward/record.url?scp=0037612282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037612282&partnerID=8YFLogxK

U2 - 10.1148/radiol.2273011768

DO - 10.1148/radiol.2273011768

M3 - Article

VL - 227

SP - 752

EP - 757

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -