Surgical methods for inner ear gene delivery in neonatal mouse

Kevin Isgrig, Wade W Chien

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Inner ear gene therapy offers great potential as a treatment for hearing loss and dizziness. The surgical method used to deliver gene therapy into the inner ear is a critical step in determining the success of inner ear gene therapy. Here we describe two commonly used surgical methods for gene delivery in neonatal mouse inner ear: The round window approach and the posterior semicircular canal approach. Both of these approaches are effective at delivering gene therapy to the neonatal mouse inner ear.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages221-226
Number of pages6
DOIs
Publication statusPublished - Jan 1 2019

Publication series

NameMethods in Molecular Biology
Volume1937
ISSN (Print)1064-3745

    Fingerprint

Keywords

  • Dizziness
  • Gene therapy
  • Hearing loss
  • Inner ear
  • Posterior semicircular canal
  • Round window

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Isgrig, K., & Chien, W. W. (2019). Surgical methods for inner ear gene delivery in neonatal mouse. In Methods in Molecular Biology (pp. 221-226). (Methods in Molecular Biology; Vol. 1937). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-9065-8_13