Surgical management of recurrent Cushing's disease in pregnancy: A case report

Mahmoud Abbassy; Varun R. Kshettry; Amir H. Hamrahian; Philip C. Johnston; Georgianna A. Dobri; Rafi Avitsian; Troy D. Woodard; Pablo F. Recinos

doi:10.4103/2152-7806.170472

Surgical management of recurrent Cushing's disease in pregnancy: A case report

Mahmoud Abbassy, Varun R. Kshettry, Amir H. Hamrahian, Philip C. Johnston, Georgianna A. Dobri, Rafi Avitsian, Troy D. Woodard, Pablo F. Recinos

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Cushing's disease is a condition rarely encountered during pregnancy. It is known that hypercortisolism is associated with increased maternal and fetal morbidity and mortality. When hypercortisolism from Cushing's disease does occur in pregnancy, the impact of achieving biochemical remission on fetal outcomes is unknown. We sought to clarify the impact of successful surgical treatment by presenting such a case report. Case Description: A 38-year-old pregnant woman with recurrent Cushing's disease after 8 years of remission. The patient had endoscopic transsphenoidal of her pituitary adenoma in her 18 ^th week of pregnancy. The patient had postoperative biochemical remission and normal fetal outcome with no maternal complications. Conclusion: Transsphenoidal surgery for Cushing's disease can be performed safely during the second trimester of pregnancy.

Original language	English (US)
Pages (from-to)	S640-S645
Journal	Surgical Neurology International
Volume	6
DOIs	https://doi.org/10.4103/2152-7806.170472
State	Published - Nov 1 2015
Externally published	Yes

Keywords

Cushing's syndrome
endonasal
endoscopic
fetal complications
minimally invasive skull base surgery
operative timing
pituitary

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.4103/2152-7806.170472

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title = "Surgical management of recurrent Cushing's disease in pregnancy: A case report",

abstract = "Background: Cushing's disease is a condition rarely encountered during pregnancy. It is known that hypercortisolism is associated with increased maternal and fetal morbidity and mortality. When hypercortisolism from Cushing's disease does occur in pregnancy, the impact of achieving biochemical remission on fetal outcomes is unknown. We sought to clarify the impact of successful surgical treatment by presenting such a case report. Case Description: A 38-year-old pregnant woman with recurrent Cushing's disease after 8 years of remission. The patient had endoscopic transsphenoidal of her pituitary adenoma in her 18 th week of pregnancy. The patient had postoperative biochemical remission and normal fetal outcome with no maternal complications. Conclusion: Transsphenoidal surgery for Cushing's disease can be performed safely during the second trimester of pregnancy.",

keywords = "Cushing's syndrome, endonasal, endoscopic, fetal complications, minimally invasive skull base surgery, operative timing, pituitary",

author = "Mahmoud Abbassy and Kshettry, {Varun R.} and Hamrahian, {Amir H.} and Johnston, {Philip C.} and Dobri, {Georgianna A.} and Rafi Avitsian and Woodard, {Troy D.} and Recinos, {Pablo F.}",

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T1 - Surgical management of recurrent Cushing's disease in pregnancy

T2 - A case report

AU - Abbassy, Mahmoud

AU - Kshettry, Varun R.

AU - Hamrahian, Amir H.

AU - Johnston, Philip C.

AU - Dobri, Georgianna A.

AU - Avitsian, Rafi

AU - Woodard, Troy D.

AU - Recinos, Pablo F.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background: Cushing's disease is a condition rarely encountered during pregnancy. It is known that hypercortisolism is associated with increased maternal and fetal morbidity and mortality. When hypercortisolism from Cushing's disease does occur in pregnancy, the impact of achieving biochemical remission on fetal outcomes is unknown. We sought to clarify the impact of successful surgical treatment by presenting such a case report. Case Description: A 38-year-old pregnant woman with recurrent Cushing's disease after 8 years of remission. The patient had endoscopic transsphenoidal of her pituitary adenoma in her 18 th week of pregnancy. The patient had postoperative biochemical remission and normal fetal outcome with no maternal complications. Conclusion: Transsphenoidal surgery for Cushing's disease can be performed safely during the second trimester of pregnancy.

AB - Background: Cushing's disease is a condition rarely encountered during pregnancy. It is known that hypercortisolism is associated with increased maternal and fetal morbidity and mortality. When hypercortisolism from Cushing's disease does occur in pregnancy, the impact of achieving biochemical remission on fetal outcomes is unknown. We sought to clarify the impact of successful surgical treatment by presenting such a case report. Case Description: A 38-year-old pregnant woman with recurrent Cushing's disease after 8 years of remission. The patient had endoscopic transsphenoidal of her pituitary adenoma in her 18 th week of pregnancy. The patient had postoperative biochemical remission and normal fetal outcome with no maternal complications. Conclusion: Transsphenoidal surgery for Cushing's disease can be performed safely during the second trimester of pregnancy.

KW - Cushing's syndrome

KW - endonasal

KW - endoscopic

KW - fetal complications

KW - minimally invasive skull base surgery

KW - operative timing

KW - pituitary

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JO - Surgical Neurology International

JF - Surgical Neurology International

ER -

Surgical management of recurrent Cushing's disease in pregnancy: A case report

Abstract

Keywords

ASJC Scopus subject areas

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