Surgical management of recurrent Cushing's disease in pregnancy: A case report

Mahmoud Abbassy, Varun R. Kshettry, Amir H. Hamrahian, Philip C. Johnston, Georgianna A. Dobri, Rafi Avitsian, Troy D. Woodard, Pablo F. Recinos

Research output: Contribution to journalArticlepeer-review


Background: Cushing's disease is a condition rarely encountered during pregnancy. It is known that hypercortisolism is associated with increased maternal and fetal morbidity and mortality. When hypercortisolism from Cushing's disease does occur in pregnancy, the impact of achieving biochemical remission on fetal outcomes is unknown. We sought to clarify the impact of successful surgical treatment by presenting such a case report. Case Description: A 38-year-old pregnant woman with recurrent Cushing's disease after 8 years of remission. The patient had endoscopic transsphenoidal of her pituitary adenoma in her 18 th week of pregnancy. The patient had postoperative biochemical remission and normal fetal outcome with no maternal complications. Conclusion: Transsphenoidal surgery for Cushing's disease can be performed safely during the second trimester of pregnancy.

Original languageEnglish (US)
Pages (from-to)S640-S645
JournalSurgical Neurology International
StatePublished - Nov 1 2015
Externally publishedYes


  • Cushing's syndrome
  • endonasal
  • endoscopic
  • fetal complications
  • minimally invasive skull base surgery
  • operative timing
  • pituitary

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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