TY - JOUR
T1 - Surgical Management of Intrahepatic Cholangiocarcinoma
T2 - Defining an Optimal Prognostic Lymph Node Stratification Schema
AU - Kim, Yuhree
AU - Spolverato, Gaya
AU - Amini, Neda
AU - Margonis, Georgios A.
AU - Gupta, Rohan
AU - Ejaz, Aslam
AU - Pawlik, Timothy M.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background: Metastatic disease to the regional lymph node (LN) is a strong predictor of worse long-term outcome after curative-intent resection of intrahepatic cholangiocarcinoma (ICC). The objectives of this study were to assess the prognostic performance of American Joint Committee on Cancer (AJCC)/International Union Against Cancer, 7th edition, N stage, LN ratio (LNR), and log odds of metastatic LN (LODDS) staging criteria in patients with ICC. Methods: The surveillance, epidemiology, and end results cancer registry was queried to identify 749 patients who underwent surgical resection of ICC during 1988–2011. The Kaplan–Meier method and Cox proportional hazards regression models were used to analyze survival. The relative discriminative abilities of the different LN staging systems were assessed by the Harrell concordance index (c statistic). Results: Of the 749 patients, 477 (63.7 %) had no LN metastasis, while 272 (36.3 %) had LN metastasis. Patients with LN metastasis had an increased risk of death (hazard ratio 2.42, 95 % confidence interval 1.98–2.95; P
AB - Background: Metastatic disease to the regional lymph node (LN) is a strong predictor of worse long-term outcome after curative-intent resection of intrahepatic cholangiocarcinoma (ICC). The objectives of this study were to assess the prognostic performance of American Joint Committee on Cancer (AJCC)/International Union Against Cancer, 7th edition, N stage, LN ratio (LNR), and log odds of metastatic LN (LODDS) staging criteria in patients with ICC. Methods: The surveillance, epidemiology, and end results cancer registry was queried to identify 749 patients who underwent surgical resection of ICC during 1988–2011. The Kaplan–Meier method and Cox proportional hazards regression models were used to analyze survival. The relative discriminative abilities of the different LN staging systems were assessed by the Harrell concordance index (c statistic). Results: Of the 749 patients, 477 (63.7 %) had no LN metastasis, while 272 (36.3 %) had LN metastasis. Patients with LN metastasis had an increased risk of death (hazard ratio 2.42, 95 % confidence interval 1.98–2.95; P
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U2 - 10.1245/s10434-015-4419-1
DO - 10.1245/s10434-015-4419-1
M3 - Article
C2 - 25663595
AN - SCOPUS:84938292813
SN - 1068-9265
VL - 22
SP - 2772
EP - 2778
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 8
ER -