Surgical Management of Hepatocellular Carcinoma: Resection or Transplantation?

Benjamin Philosophe, Paul D. Greig, Alan W. Hemming, Mark S. Cattral, Ian Wanless, Imran Rasul, Nancy Baxter, Bryce R. Taylor, Bernard Langer

Research output: Contribution to journalArticle

Abstract

Liver resection or transplantation offers the best opportunity for cure of hepatocellular carcinoma (HCC). To determine the relative roles for resection and transplantation and to evaluate the patient and tumor characteristics that might predict survival, the records of 125 patients treated for nonfibrolamellar HCC at The Toronto Hospital between 1981 and 1996 were reviewed. No adjuvant chemotherapy or antiviral protocols were used. Resection was the first operation in 67 patients; one underwent re-resection. Sixty patients underwent transplantation including two who had previously had a resection; 40 had known or suspected HCC and 20 had incidental tumors identified in the explanted liver. The incidence of cirrhosis was 49% for resection and 88% for transplantation. The incidence of hepatitis B virus (HBV) was 58% and 33%, respectively. The operative mortality rate for resection was 4.4% (9.4% in cirrhotic and 0 in noncirrhotic patients) and 13.3% for transplantation. The 5-year cumulative recurrence rate was 55% following resection and 20% following transplantation (P

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume2
Issue number1
StatePublished - Jan 1998
Externally publishedYes

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Hepatocellular Carcinoma
Transplantation
Liver
Incidence
Adjuvant Chemotherapy
Hepatitis B virus
Antiviral Agents
Neoplasms
Fibrosis
Recurrence
Survival
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Philosophe, B., Greig, P. D., Hemming, A. W., Cattral, M. S., Wanless, I., Rasul, I., ... Langer, B. (1998). Surgical Management of Hepatocellular Carcinoma: Resection or Transplantation? Journal of Gastrointestinal Surgery, 2(1), 21-27.

Surgical Management of Hepatocellular Carcinoma : Resection or Transplantation? / Philosophe, Benjamin; Greig, Paul D.; Hemming, Alan W.; Cattral, Mark S.; Wanless, Ian; Rasul, Imran; Baxter, Nancy; Taylor, Bryce R.; Langer, Bernard.

In: Journal of Gastrointestinal Surgery, Vol. 2, No. 1, 01.1998, p. 21-27.

Research output: Contribution to journalArticle

Philosophe, B, Greig, PD, Hemming, AW, Cattral, MS, Wanless, I, Rasul, I, Baxter, N, Taylor, BR & Langer, B 1998, 'Surgical Management of Hepatocellular Carcinoma: Resection or Transplantation?', Journal of Gastrointestinal Surgery, vol. 2, no. 1, pp. 21-27.
Philosophe B, Greig PD, Hemming AW, Cattral MS, Wanless I, Rasul I et al. Surgical Management of Hepatocellular Carcinoma: Resection or Transplantation? Journal of Gastrointestinal Surgery. 1998 Jan;2(1):21-27.
Philosophe, Benjamin ; Greig, Paul D. ; Hemming, Alan W. ; Cattral, Mark S. ; Wanless, Ian ; Rasul, Imran ; Baxter, Nancy ; Taylor, Bryce R. ; Langer, Bernard. / Surgical Management of Hepatocellular Carcinoma : Resection or Transplantation?. In: Journal of Gastrointestinal Surgery. 1998 ; Vol. 2, No. 1. pp. 21-27.
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