Surgical and molecular pathology of pancreatic neoplasms

Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus, Lodewijk A.A. Brosens

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Background: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. Main body: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. Conclusion: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.

Original languageEnglish (US)
Article number47
JournalDiagnostic Pathology
Issue number1
StatePublished - Jun 7 2016


  • Acinar cell carcinoma
  • Genetics
  • Histology
  • Methylation
  • MicroRNA
  • Pancreas
  • Pancreatic cancer
  • Pancreatic neuroendocrine tumor
  • Sequencing
  • Solid-pseudopapillary neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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