Surgical and molecular pathology of pancreatic neoplasms

Wenzel M. Hackeng, Ralph H. Hruban, G. Johan A. Offerhaus, Lodewijk A.A. Brosens

Research output: Contribution to journalReview article

Abstract

Background: Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. Main body: Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of the underlying biology of pancreatic neoplasia. These advances have not only confirmed the traditional histologic classification system, but also opened new doors to early diagnosis and targeted treatment. Conclusion: This review discusses the histopathology, genetic and epigenetic alterations and potential treatment targets of the five major malignant pancreatic tumors - pancreatic ductal adenocarcinoma, pancreatic neuroendocrine tumor, solid-pseudopapillary neoplasm, acinar cell carcinoma and pancreatoblastoma.

Original languageEnglish (US)
Article number47
JournalDiagnostic Pathology
Volume11
Issue number1
DOIs
StatePublished - Jun 7 2016

Keywords

  • Acinar cell carcinoma
  • Genetics
  • Histology
  • Methylation
  • MicroRNA
  • Pancreas
  • Pancreatic cancer
  • Pancreatic neuroendocrine tumor
  • Sequencing
  • Solid-pseudopapillary neoplasm

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Fingerprint Dive into the research topics of 'Surgical and molecular pathology of pancreatic neoplasms'. Together they form a unique fingerprint.

  • Cite this