Surgery insight: Deep brain stimulation for movement disorders

Research output: Contribution to journalReview article

Abstract

Over the past two decades, deep brain stimulation (DBS) has supplanted lesioning techniques for the treatment of movement disorders, and has been shown to be safe and efficacious. The primary therapeutic indications for DBS are essential tremor, dystonia and Parkinson's disease. In the case of Parkinson's disease, DBS is effective for treating the primary symptoms - tremor, bradykinesia and rigidity - as well as the motor complications of drug treatment. Progress has been made in understanding the effects of stimulation at the neuronal level, and this knowledge should eventually improve the effectiveness of this therapy. Preliminary studies also indicate that DBS might be used to treat Tourette's syndrome, obsessive-compulsive disorder, depression and epilepsy. As we will discuss in this review, the success of DBS depends on an appropriate rationale for the procedure, and on collaborations between neurologists and neurosurgeons in defining outcomes.

Original languageEnglish (US)
Pages (from-to)310-320
Number of pages11
JournalNature Clinical Practice Neurology
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2006

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Keywords

  • Clinical electrophysiology
  • Deep brain stimulation
  • Microelectrode recording
  • Movement disorders
  • Stereotactic surgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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