Surgery for unusual histopathologic variants of esophageal neoplasms: A report of 23 cases with emphasis on histopathologic characteristics

J. M. Klaase, J. B F Hulscher, G. J A Offerhaus, F. J W Ten Kate, H. Obertop, J. J B Van Lanschot

Research output: Contribution to journalArticle

Abstract

Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse. Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000. Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature. Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalAnnals of Surgical Oncology
Volume10
Issue number3
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Esophageal Neoplasms
Small Cell Carcinoma
Squamous Cell Carcinoma
Adenosquamous Carcinoma
Carcinosarcoma
Neoplasms
Gastrointestinal Stromal Tumors
Survival
Leiomyosarcoma
Leiomyoma
Clinical Protocols
Melanoma
Adenocarcinoma
Databases
Drug Therapy
Therapeutics

Keywords

  • Esophageal neoplasms
  • Histopathological characteristics
  • Small-cell carcinoma
  • Unusual variants

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Klaase, J. M., Hulscher, J. B. F., Offerhaus, G. J. A., Ten Kate, F. J. W., Obertop, H., & Van Lanschot, J. J. B. (2003). Surgery for unusual histopathologic variants of esophageal neoplasms: A report of 23 cases with emphasis on histopathologic characteristics. Annals of Surgical Oncology, 10(3), 261-267. https://doi.org/10.1245/ASO.2003.05.029

Surgery for unusual histopathologic variants of esophageal neoplasms : A report of 23 cases with emphasis on histopathologic characteristics. / Klaase, J. M.; Hulscher, J. B F; Offerhaus, G. J A; Ten Kate, F. J W; Obertop, H.; Van Lanschot, J. J B.

In: Annals of Surgical Oncology, Vol. 10, No. 3, 2003, p. 261-267.

Research output: Contribution to journalArticle

Klaase, J. M. ; Hulscher, J. B F ; Offerhaus, G. J A ; Ten Kate, F. J W ; Obertop, H. ; Van Lanschot, J. J B. / Surgery for unusual histopathologic variants of esophageal neoplasms : A report of 23 cases with emphasis on histopathologic characteristics. In: Annals of Surgical Oncology. 2003 ; Vol. 10, No. 3. pp. 261-267.
@article{45789905aaee49bc830a4d988bb09e17,
title = "Surgery for unusual histopathologic variants of esophageal neoplasms: A report of 23 cases with emphasis on histopathologic characteristics",
abstract = "Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1{\%} to 7{\%} of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse. Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000. Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3{\%}). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature. Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.",
keywords = "Esophageal neoplasms, Histopathological characteristics, Small-cell carcinoma, Unusual variants",
author = "Klaase, {J. M.} and Hulscher, {J. B F} and Offerhaus, {G. J A} and {Ten Kate}, {F. J W} and H. Obertop and {Van Lanschot}, {J. J B}",
year = "2003",
doi = "10.1245/ASO.2003.05.029",
language = "English (US)",
volume = "10",
pages = "261--267",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Surgery for unusual histopathologic variants of esophageal neoplasms

T2 - A report of 23 cases with emphasis on histopathologic characteristics

AU - Klaase, J. M.

AU - Hulscher, J. B F

AU - Offerhaus, G. J A

AU - Ten Kate, F. J W

AU - Obertop, H.

AU - Van Lanschot, J. J B

PY - 2003

Y1 - 2003

N2 - Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse. Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000. Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature. Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

AB - Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse. Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000. Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature. Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

KW - Esophageal neoplasms

KW - Histopathological characteristics

KW - Small-cell carcinoma

KW - Unusual variants

UR - http://www.scopus.com/inward/record.url?scp=0038809973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038809973&partnerID=8YFLogxK

U2 - 10.1245/ASO.2003.05.029

DO - 10.1245/ASO.2003.05.029

M3 - Article

C2 - 12679311

AN - SCOPUS:0038809973

VL - 10

SP - 261

EP - 267

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 3

ER -