Surgery for unusual histopathologic variants of esophageal neoplasms: A report of 23 cases with emphasis on histopathologic characteristics

J. M. Klaase, J. B F Hulscher, G. J A Offerhaus, F. J W Ten Kate, H. Obertop, J. J B Van Lanschot

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Adenocarcinoma and squamous cell carcinoma are the most frequent pathologic diagnoses with esophageal malignancy. Unusual pathologic variants are encountered in only 1% to 7% of patients, and therefore data evaluating the treatment and survival in this group of esophageal neoplasms are sparse. Methods: To get more insight into the unusual pathologic variants, patients were selected from our computer-assisted database containing data from 426 consecutive patients treated with esophageal resection or enucleation at our institute during 1993 to 2000. Results: Uncommon variants of esophageal neoplasms were encountered in 23 patients (5.3%). The following unusual histopathologic variants were seen: basaloid squamous cell carcinoma (n = 3), small-cell carcinoma (n = 1), leiomyoma (n = 5), gastrointestinal stromal tumor (n = 2), leiomyosarcoma (n = 1), adenosquamous carcinoma (n = 5), carcinosarcoma (n = 4), collision tumor (n = 1), and melanoma (n = 1). Presentation, histopathologic characteristics, treatment, and prognosis are described in reference to the existing literature. Conclusions: Survival data of the unusual pathologic variants seem to be comparable to those of the most frequently encountered neoplasms. Only in case of small-cell carcinoma does there seem to be a definite role for chemotherapy, especially in a multimodality treatment protocol.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalAnnals of Surgical Oncology
Volume10
Issue number3
DOIs
StatePublished - 2003
Externally publishedYes

Keywords

  • Esophageal neoplasms
  • Histopathological characteristics
  • Small-cell carcinoma
  • Unusual variants

ASJC Scopus subject areas

  • Surgery
  • Oncology

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