Surgery for oligometastasis of pancreatic cancer

Fengchun Lu; Katherine E. Poruk; Matthew J. Weiss

doi:10.3978/j.issn.1000-9604.2015.05.02

Surgery for oligometastasis of pancreatic cancer

Fengchun Lu, Katherine E. Poruk, Matthew J. Weiss

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.

Original language	English (US)
Pages (from-to)	358-367
Number of pages	10
Journal	Chinese Journal of Cancer Research
Volume	27
Issue number	4
DOIs	https://doi.org/10.3978/j.issn.1000-9604.2015.05.02
State	Published - Jan 1 2015

Keywords

Hepatic metastasis
Oligometastasis
Pancreatic cancer (PC)
Pulmonary metastasis
Surgical management

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3978/j.issn.1000-9604.2015.05.02

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title = "Surgery for oligometastasis of pancreatic cancer",

abstract = "The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.",

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AU - Lu, Fengchun

AU - Poruk, Katherine E.

AU - Weiss, Matthew J.

PY - 2015/1/1

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N2 - The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.

AB - The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.

KW - Hepatic metastasis

KW - Oligometastasis

KW - Pancreatic cancer (PC)

KW - Pulmonary metastasis

KW - Surgical management

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Surgery for oligometastasis of pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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