Abstract
The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 358-367 |
| Number of pages | 10 |
| Journal | Chinese Journal of Cancer Research |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2015 |
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Keywords
- Hepatic metastasis
- Oligometastasis
- Pancreatic cancer (PC)
- Pulmonary metastasis
- Surgical management
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Surgery for oligometastasis of pancreatic cancer. / Lu, Fengchun; Poruk, Katherine E.; Weiss, Matthew J.
In: Chinese Journal of Cancer Research, Vol. 27, No. 4, 2015, p. 358-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Surgery for oligometastasis of pancreatic cancer
AU - Lu, Fengchun
AU - Poruk, Katherine E.
AU - Weiss, Matthew J
PY - 2015
Y1 - 2015
N2 - The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.
AB - The incidence of pancreatic adenocarcinoma (PDAC) has steadily increased over the past several decades. The majority of PDAC patients will present with distant metastases, limiting surgical management in this population. Hepatectomy and pulmonary metastasectomy (PM) has been well established for colorectal cancer patients with isolated, resectable hepatic or pulmonary metastatic disease. Recent advancements in effective systemic therapy for PDAC have led to the selection of certain patients where metastectomy may be potentially indicated. However, the indication for resection of oligometastases in PDAC is not well defined. This review will discuss the current literature on the surgical management of metastatic disease for PDAC with a specific focus on surgical resection for isolated hepatic and pulmonary metastases.
KW - Hepatic metastasis
KW - Oligometastasis
KW - Pancreatic cancer (PC)
KW - Pulmonary metastasis
KW - Surgical management
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UR - http://www.scopus.com/inward/citedby.url?scp=84940562523&partnerID=8YFLogxK
U2 - 10.3978/j.issn.1000-9604.2015.05.02
DO - 10.3978/j.issn.1000-9604.2015.05.02
M3 - Article
C2 - 26361405
AN - SCOPUS:84940562523
VL - 27
SP - 358
EP - 367
JO - Chinese Journal of Cancer Research
JF - Chinese Journal of Cancer Research
SN - 1000-9604
IS - 4
ER -