Surgery for hilar cholangiocarcinoma: The Johns Hopkins approach

Keith D. Lillemoe, John L Cameron

Research output: Contribution to journalArticle

Abstract

Carcinoma of the hepatic duct confluence is the most common site of bile duct malignancies. Significant progress has been made in recent years in the diagnosis and treatment of this disease. The diagnosis is generally made in the jaundiced patient with contrast-enhanced spiral computed tomography (CT) scanning followed by cholangiography. Percutaneous transhepatic cholangiography is favored over endoscopic retrograde cholangiography in that it better defines the proximal extent of the tumor involvement and allows placement of percutaneous transhepatic catheters. The preoperative placement of stents facilitates the surgical management, as well as decompressing the obstructed biliary tree. The operative technique at The Johns Hopkins Hospital involves resection of the hepatic confluence and reconstruction over Silastic stents. In patients in whom the hilar cholangiocarcinoma extends along either the right or left hepatic duct into the hepatic parenchyma, appropriate hepatic lobectomy is performed. A recent review of the Johns Hopkins experience has demonstrated that 67% of cholangiocarcinomas are located in the perihilar location. Fifty-six percent of these patients were resectable for potential cure. Of the 109 resected patients, 4 patients (3.6%) died secondary to complications of sepsis. In the 109 patients with resected perihilar tumors, the 1-, 3-, and 5-year survival was 68%, 30% and 11%, respectively. The median survival was 19 months. The addition of hepatic lobectomy did not alter the survival rate. Negative margins and negative lymph node status were associated with improved survival. Postoperative adjuvant radiation therapy did not provide benefit to patients with resected perihilar carcinoma.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume7
Issue number2
StatePublished - 2000

Fingerprint

Klatskin Tumor
Cholangiography
Common Hepatic Duct
Liver
Stents
Survival
Carcinoma
Neoplasms
Cholangiocarcinoma
Spiral Computed Tomography
Common Bile Duct
Biliary Tract
Jaundice
Sepsis
Radiotherapy
Catheters
Survival Rate
Lymph Nodes

ASJC Scopus subject areas

  • Surgery

Cite this

Surgery for hilar cholangiocarcinoma : The Johns Hopkins approach. / Lillemoe, Keith D.; Cameron, John L.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 7, No. 2, 2000, p. 115-121.

Research output: Contribution to journalArticle

@article{af92abed7bdd4b17b2b7c92e644af25f,
title = "Surgery for hilar cholangiocarcinoma: The Johns Hopkins approach",
abstract = "Carcinoma of the hepatic duct confluence is the most common site of bile duct malignancies. Significant progress has been made in recent years in the diagnosis and treatment of this disease. The diagnosis is generally made in the jaundiced patient with contrast-enhanced spiral computed tomography (CT) scanning followed by cholangiography. Percutaneous transhepatic cholangiography is favored over endoscopic retrograde cholangiography in that it better defines the proximal extent of the tumor involvement and allows placement of percutaneous transhepatic catheters. The preoperative placement of stents facilitates the surgical management, as well as decompressing the obstructed biliary tree. The operative technique at The Johns Hopkins Hospital involves resection of the hepatic confluence and reconstruction over Silastic stents. In patients in whom the hilar cholangiocarcinoma extends along either the right or left hepatic duct into the hepatic parenchyma, appropriate hepatic lobectomy is performed. A recent review of the Johns Hopkins experience has demonstrated that 67{\%} of cholangiocarcinomas are located in the perihilar location. Fifty-six percent of these patients were resectable for potential cure. Of the 109 resected patients, 4 patients (3.6{\%}) died secondary to complications of sepsis. In the 109 patients with resected perihilar tumors, the 1-, 3-, and 5-year survival was 68{\%}, 30{\%} and 11{\%}, respectively. The median survival was 19 months. The addition of hepatic lobectomy did not alter the survival rate. Negative margins and negative lymph node status were associated with improved survival. Postoperative adjuvant radiation therapy did not provide benefit to patients with resected perihilar carcinoma.",
author = "Lillemoe, {Keith D.} and Cameron, {John L}",
year = "2000",
language = "English (US)",
volume = "7",
pages = "115--121",
journal = "Journal of Hepato-Biliary-Pancreatic Sciences",
issn = "1868-6974",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Surgery for hilar cholangiocarcinoma

T2 - The Johns Hopkins approach

AU - Lillemoe, Keith D.

AU - Cameron, John L

PY - 2000

Y1 - 2000

N2 - Carcinoma of the hepatic duct confluence is the most common site of bile duct malignancies. Significant progress has been made in recent years in the diagnosis and treatment of this disease. The diagnosis is generally made in the jaundiced patient with contrast-enhanced spiral computed tomography (CT) scanning followed by cholangiography. Percutaneous transhepatic cholangiography is favored over endoscopic retrograde cholangiography in that it better defines the proximal extent of the tumor involvement and allows placement of percutaneous transhepatic catheters. The preoperative placement of stents facilitates the surgical management, as well as decompressing the obstructed biliary tree. The operative technique at The Johns Hopkins Hospital involves resection of the hepatic confluence and reconstruction over Silastic stents. In patients in whom the hilar cholangiocarcinoma extends along either the right or left hepatic duct into the hepatic parenchyma, appropriate hepatic lobectomy is performed. A recent review of the Johns Hopkins experience has demonstrated that 67% of cholangiocarcinomas are located in the perihilar location. Fifty-six percent of these patients were resectable for potential cure. Of the 109 resected patients, 4 patients (3.6%) died secondary to complications of sepsis. In the 109 patients with resected perihilar tumors, the 1-, 3-, and 5-year survival was 68%, 30% and 11%, respectively. The median survival was 19 months. The addition of hepatic lobectomy did not alter the survival rate. Negative margins and negative lymph node status were associated with improved survival. Postoperative adjuvant radiation therapy did not provide benefit to patients with resected perihilar carcinoma.

AB - Carcinoma of the hepatic duct confluence is the most common site of bile duct malignancies. Significant progress has been made in recent years in the diagnosis and treatment of this disease. The diagnosis is generally made in the jaundiced patient with contrast-enhanced spiral computed tomography (CT) scanning followed by cholangiography. Percutaneous transhepatic cholangiography is favored over endoscopic retrograde cholangiography in that it better defines the proximal extent of the tumor involvement and allows placement of percutaneous transhepatic catheters. The preoperative placement of stents facilitates the surgical management, as well as decompressing the obstructed biliary tree. The operative technique at The Johns Hopkins Hospital involves resection of the hepatic confluence and reconstruction over Silastic stents. In patients in whom the hilar cholangiocarcinoma extends along either the right or left hepatic duct into the hepatic parenchyma, appropriate hepatic lobectomy is performed. A recent review of the Johns Hopkins experience has demonstrated that 67% of cholangiocarcinomas are located in the perihilar location. Fifty-six percent of these patients were resectable for potential cure. Of the 109 resected patients, 4 patients (3.6%) died secondary to complications of sepsis. In the 109 patients with resected perihilar tumors, the 1-, 3-, and 5-year survival was 68%, 30% and 11%, respectively. The median survival was 19 months. The addition of hepatic lobectomy did not alter the survival rate. Negative margins and negative lymph node status were associated with improved survival. Postoperative adjuvant radiation therapy did not provide benefit to patients with resected perihilar carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0033655729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033655729&partnerID=8YFLogxK

M3 - Article

C2 - 10982602

AN - SCOPUS:0033655729

VL - 7

SP - 115

EP - 121

JO - Journal of Hepato-Biliary-Pancreatic Sciences

JF - Journal of Hepato-Biliary-Pancreatic Sciences

SN - 1868-6974

IS - 2

ER -