Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

Wu Yuan; H. P. Ho; C. L. Wong; S. K. Kong; Chinlon Lin

doi:10.1109/JSEN.2006.884982

Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

Wu Yuan, H. P. Ho, C. L. Wong, S. K. Kong, Chinlon Lin

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

Original language	English (US)
Pages (from-to)	70-73
Number of pages	4
Journal	IEEE Sensors Journal
Volume	7
Issue number	1
DOIs	https://doi.org/10.1109/JSEN.2006.884982
State	Published - Jan 2007
Externally published	Yes

Keywords

Biosensor
Interferometry
Phase interrogation
Surface plasmon resonance

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering

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10.1109/JSEN.2006.884982

Cite this

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title = "Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity",

abstract = "A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.",

keywords = "Biosensor, Interferometry, Phase interrogation, Surface plasmon resonance",

author = "Wu Yuan and Ho, {H. P.} and Wong, {C. L.} and Kong, {S. K.} and Chinlon Lin",

note = "Funding Information: Manuscript received April 28, 2006; revised July 1, 2006 and July 30, 2006. This work was supported by RGC under Grant CUHK4186/04E and by the Shun Hing Institute of Advanced Engineering. The work of W. Yuan was supported by The Chinese University of Hong Kong. The associate editor coordinating the review of this paper and approving it for publication was Dr. Jenny Gun.",

year = "2007",

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doi = "10.1109/JSEN.2006.884982",

language = "English (US)",

volume = "7",

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journal = "IEEE Sensors Journal",

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publisher = "Institute of Electrical and Electronics Engineers Inc.",

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AU - Yuan, Wu

AU - Ho, H. P.

AU - Wong, C. L.

AU - Kong, S. K.

AU - Lin, Chinlon

N1 - Funding Information: Manuscript received April 28, 2006; revised July 1, 2006 and July 30, 2006. This work was supported by RGC under Grant CUHK4186/04E and by the Shun Hing Institute of Advanced Engineering. The work of W. Yuan was supported by The Chinese University of Hong Kong. The associate editor coordinating the review of this paper and approving it for publication was Dr. Jenny Gun.

PY - 2007/1

Y1 - 2007/1

N2 - A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

AB - A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer.

KW - Biosensor

KW - Interferometry

KW - Phase interrogation

KW - Surface plasmon resonance

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Surface plasmon resonance biosensor incorporated in a michelson interferometer with enhanced sensitivity

Abstract

Keywords

ASJC Scopus subject areas

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