TY - JOUR
T1 - Surface engineering for lymphocyte programming
AU - Ben-Akiva, Elana
AU - Meyer, Randall A.
AU - Wilson, David R.
AU - Green, Jordan J.
N1 - Funding Information:
The authors wish to thank the NIH ( R01EB022148 and R01CA195503 ), the Johns Hopkins University Discovery Award , and the Johns Hopkins Bloomberg—Kimmel Institute for Cancer Immunotherapy for their support. RAM thanks the National Cancer Institute at the National Institute of Health (NIH F31CA214147), the Institute for Nanobiotechnology, and the Achievement Rewards for College Scientists program for fellowship support. DRW thanks the NSF Graduate Research Fellowship for support (DGE-0707427).
Funding Information:
The authors wish to thank the NIH (R01EB022148 and R01CA195503), the Johns Hopkins University Discovery Award, and the Johns Hopkins Bloomberg?Kimmel Institute for Cancer Immunotherapy for their support. RAM thanks the National Cancer Institute at the National Institute of Health (NIH F31CA214147), the Institute for Nanobiotechnology, and the Achievement Rewards for College Scientists program for fellowship support. DRW thanks the NSF Graduate Research Fellowship for support (DGE-0707427).
Publisher Copyright:
© 2017 Elsevier B.V.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/5/15
Y1 - 2017/5/15
N2 - The once nascent field of immunoengineering has recently blossomed to include approaches to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer cells are in preclinical and clinical development. Surfaces have been engineered at the molecular level in terms of the presence of specific biological factors, their arrangement on a surface, and their diffusivity to elicit specific lymphocyte fates. In addition, the physical and mechanical characteristics of the surface including shape, anisotropy, and rigidity of particles for lymphocyte activation have been fine-tuned. Utilizing these strategies, acellular systems have been engineered for the expansion of T-Cells and natural killer cells to clinically relevant levels for cancer therapies as well as engineered to program B-Cells to better combat infectious diseases.
AB - The once nascent field of immunoengineering has recently blossomed to include approaches to deliver and present biomolecules to program diverse populations of lymphocytes to fight disease. Building upon improved understanding of the molecular and physical mechanics of lymphocyte activation, varied strategies for engineering surfaces to activate and deactivate T-Cells, B-Cells and natural killer cells are in preclinical and clinical development. Surfaces have been engineered at the molecular level in terms of the presence of specific biological factors, their arrangement on a surface, and their diffusivity to elicit specific lymphocyte fates. In addition, the physical and mechanical characteristics of the surface including shape, anisotropy, and rigidity of particles for lymphocyte activation have been fine-tuned. Utilizing these strategies, acellular systems have been engineered for the expansion of T-Cells and natural killer cells to clinically relevant levels for cancer therapies as well as engineered to program B-Cells to better combat infectious diseases.
KW - Artificial antigen presenting cell
KW - Lymphocyte engineering
KW - Microparticle
KW - Nanoparticle
UR - http://www.scopus.com/inward/record.url?scp=85019347850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019347850&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2017.05.005
DO - 10.1016/j.addr.2017.05.005
M3 - Review article
C2 - 28501510
AN - SCOPUS:85019347850
VL - 114
SP - 102
EP - 115
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -