Supratentorial cortical ependymoma

Report of three cases

Federico Roncaroli, Alessandro Consales, Antonio Fioravanti, Giovanna Cenacchi, Jon David Weingart, Jeffrey N. Bruce, Giovanni Broggi

Research output: Contribution to journalArticle

Abstract

OBJECTIVE AND IMPORTANCE: Extraventricular ependymomas account for 50% of supratentorial ependymomas. Some tumors may extend to the gray matter reaching the pial surface, but pure cortical ependymomas are uncommon. Here, we report three patients with supratentorial intracortical ependymoma. CLINICAL PRESENTATION: We reviewed the clinicopathological findings of all patients operated on for ependymomas at the Bellaria Hospital during an 11-year period and found three lesions described as cortical ependymomas. The three lesions represented 2.5% of all ependymal tumors and 21.4% of supratentorial tumors operated on during the study period. The patient were aged 52, 24, and 11 years (mean, 32.3 yr). One was female. All presented with seizures. On imaging, the lesions were confined to the gray matter, were solid, and demonstrated diffuse enhancement. INTERVENTION: Gross total resection was achieved in all instances. Two patients were treated with surgery, and one was treated with surgery and postoperative radiotherapy. All tumors were low grade. After a mean follow-up of 92.6 months, no patient had recurrence or leptomeningeal dissemination. Review of preoperative magnetic resonance imaging scans confirmed an intracortical location. Routine sections were reviewed, and additional immunoreactions for epithelial membrane antigen, glial fibrillary acidic protein, synaptophysin, neurofilament proteins, S-100 protein, and Ki-67 and electron microscopy were performed. CONCLUSION: Cortical ependymomas seem to behave as benign tumors amenable to surgical removal. Local recurrence and leptomeningeal dissemination seem to be unlikely. Postoperative radiotherapy is unnecessary.

Original languageEnglish (US)
Pages (from-to)192
Number of pages1
JournalNeurosurgery
Volume57
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Ependymoma
Neoplasms
Radiotherapy
Supratentorial Neoplasms
Neurofilament Proteins
Recurrence
Mucin-1
Synaptophysin
S100 Proteins
Glial Fibrillary Acidic Protein
Protein S
Electron Microscopy
Seizures
Magnetic Resonance Imaging

Keywords

  • Cortical
  • Ectopic
  • Ependymoma
  • Supratentorial

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Roncaroli, F., Consales, A., Fioravanti, A., Cenacchi, G., Weingart, J. D., Bruce, J. N., & Broggi, G. (2005). Supratentorial cortical ependymoma: Report of three cases. Neurosurgery, 57(1), 192. https://doi.org/10.1227/01.NEU.0000164171.29292.D6

Supratentorial cortical ependymoma : Report of three cases. / Roncaroli, Federico; Consales, Alessandro; Fioravanti, Antonio; Cenacchi, Giovanna; Weingart, Jon David; Bruce, Jeffrey N.; Broggi, Giovanni.

In: Neurosurgery, Vol. 57, No. 1, 07.2005, p. 192.

Research output: Contribution to journalArticle

Roncaroli, F, Consales, A, Fioravanti, A, Cenacchi, G, Weingart, JD, Bruce, JN & Broggi, G 2005, 'Supratentorial cortical ependymoma: Report of three cases', Neurosurgery, vol. 57, no. 1, pp. 192. https://doi.org/10.1227/01.NEU.0000164171.29292.D6
Roncaroli F, Consales A, Fioravanti A, Cenacchi G, Weingart JD, Bruce JN et al. Supratentorial cortical ependymoma: Report of three cases. Neurosurgery. 2005 Jul;57(1):192. https://doi.org/10.1227/01.NEU.0000164171.29292.D6
Roncaroli, Federico ; Consales, Alessandro ; Fioravanti, Antonio ; Cenacchi, Giovanna ; Weingart, Jon David ; Bruce, Jeffrey N. ; Broggi, Giovanni. / Supratentorial cortical ependymoma : Report of three cases. In: Neurosurgery. 2005 ; Vol. 57, No. 1. pp. 192.
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