Suppressor cells in transplantation tolerance

I suppressor cells in the mechanism of tolerance in radiation chimeras

Peter J. Tutschka, Allan D. Hess, William E. Beschorner, George W. Santos

Research output: Contribution to journalArticle

Abstract

Histoincompatible-complete radiation chimeras, after resolving acute graft-versus-host disease (GVHD), establish specific tolerance to host and donor alloantigens. This tolerance can be perturbed with immunosuppressive agents and infusions of small numbers of donor-type cells, with infusions of massive numbers of donor-type cells, or with infusions of a small number of donor-type cells, that were sensitized against host antigens prior to transfer. These chimeras possess T lymphocytes in the spleen that specifically suppress donor to host mixed lymphocyte reactions and adoptively transfer suppression of GVHD to secondary hosts. Nylon-wool fractionation of chimeric spleen cells restores the response of chimeric lymphocytes to host alloantigens, suggesting that transplantation tolerance is not attributable to clonal deletion but the activity of nylon-wool-adherent T suppressor spleen cells.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalTransplantation
Volume32
Issue number3
StatePublished - 1981

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Radiation Chimera
Transplantation Tolerance
Cell Transplantation
Spleen
Isoantigens
Wool
Cell Count
Nylons
Graft vs Host Disease
Clonal Deletion
Mixed Lymphocyte Culture Test
Immunosuppressive Agents
Lymphocytes
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Tutschka, P. J., Hess, A. D., Beschorner, W. E., & Santos, G. W. (1981). Suppressor cells in transplantation tolerance: I suppressor cells in the mechanism of tolerance in radiation chimeras. Transplantation, 32(3), 203-209.

Suppressor cells in transplantation tolerance : I suppressor cells in the mechanism of tolerance in radiation chimeras. / Tutschka, Peter J.; Hess, Allan D.; Beschorner, William E.; Santos, George W.

In: Transplantation, Vol. 32, No. 3, 1981, p. 203-209.

Research output: Contribution to journalArticle

Tutschka, PJ, Hess, AD, Beschorner, WE & Santos, GW 1981, 'Suppressor cells in transplantation tolerance: I suppressor cells in the mechanism of tolerance in radiation chimeras', Transplantation, vol. 32, no. 3, pp. 203-209.
Tutschka, Peter J. ; Hess, Allan D. ; Beschorner, William E. ; Santos, George W. / Suppressor cells in transplantation tolerance : I suppressor cells in the mechanism of tolerance in radiation chimeras. In: Transplantation. 1981 ; Vol. 32, No. 3. pp. 203-209.
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