Suppressive effects of interleukin-10 on human mononuclear phagocyte function against Candida albicans and Staphylococcus aureus

Emmanuel Roilides, Anastasia Anastasiou-Katsiardani, Anastasia Dimitriadou-Georgiadou, Isaac Kadiltsoglou, Sevasti Tsaparidou, Christos Panteliadis, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

The effects of interleukin (IL)-10, a potent antiinflammatory cytokine, on human monocyte functions against two medically important pathogens, Candida albicans and Staphylococcus aureus, were studied. Incubation with 20- 100 ng/mL IL-10 for 2-3 days decreased the fungicidal activity of monocytes against serum-opsonized C. albicans blastoconidia (P ≤ .04), reduced their capacity to damage unopsonized hyphae (P ≤ .006), and suppressed superoxide anion production in response to phorbol myristate acetate (P = .019) and N- FMLP (P = .04) but not to serum-opsonized blastoconidia. Paradoxically, IL- 10 enhanced phagocytic activity of monocytes against serum-opsonized blastoconidia (P<.01). In addition, IL-10-treated monocytes demonstrated decreased bactericidal activity (P = .046) but no change in bacterial phagocytosis. These findings demonstrate an overall suppressive role of IL- 10 on human monocyte function against C. albicans and S. aureus and may have important implications in the use of this cytokine.

Original languageEnglish (US)
Pages (from-to)1734-1742
Number of pages9
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - Dec 18 1998

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Roilides, E., Anastasiou-Katsiardani, A., Dimitriadou-Georgiadou, A., Kadiltsoglou, I., Tsaparidou, S., Panteliadis, C., & Walsh, T. J. (1998). Suppressive effects of interleukin-10 on human mononuclear phagocyte function against Candida albicans and Staphylococcus aureus. Journal of Infectious Diseases, 178(6), 1734-1742. https://doi.org/10.1086/314479