Abstract
Intravenous administration of Type II collagen to rats prior to immunization with Type II collagen suppresses hind paw inflammation, humoral response to Type II collagen, and the severity of the arthritic lesion. Suppression of inflammation and its severity as well as the humoral response can also be induced by the prior intravenous administration of α1 (II) CB10 a cyanogen bromide peptide derived from Type II collagen. Suppression of arthritis is disease specific; intravenous administration of either Type II collagen or α1 (II) CB10 does not have an effect on adjuvant-induced arthritis. These studies indicate that structural determinants of α1 (II) CB10 (Mr, 30,000), a peptide located near the carboxy terminus of the collagen molecule, can induce suppression and suggest that these determinants may be responsible for the suppression of arthritis when Type II collagen is administered intravenously.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 357-365 |
| Number of pages | 9 |
| Journal | Cellular Immunology |
| Volume | 87 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Suppression of type II collagen-induced arthritis by the intravenous administration of type II collagen or its constituent peptide α1, (II) CB10. / Englert, Mary E.; Landes, Mary Jane; Oronsky, Arnold L.; Kerwar, S. S.
In: Cellular Immunology, Vol. 87, No. 2, 1984, p. 357-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppression of type II collagen-induced arthritis by the intravenous administration of type II collagen or its constituent peptide α1, (II) CB10
AU - Englert, Mary E.
AU - Landes, Mary Jane
AU - Oronsky, Arnold L.
AU - Kerwar, S. S.
PY - 1984
Y1 - 1984
N2 - Intravenous administration of Type II collagen to rats prior to immunization with Type II collagen suppresses hind paw inflammation, humoral response to Type II collagen, and the severity of the arthritic lesion. Suppression of inflammation and its severity as well as the humoral response can also be induced by the prior intravenous administration of α1 (II) CB10 a cyanogen bromide peptide derived from Type II collagen. Suppression of arthritis is disease specific; intravenous administration of either Type II collagen or α1 (II) CB10 does not have an effect on adjuvant-induced arthritis. These studies indicate that structural determinants of α1 (II) CB10 (Mr, 30,000), a peptide located near the carboxy terminus of the collagen molecule, can induce suppression and suggest that these determinants may be responsible for the suppression of arthritis when Type II collagen is administered intravenously.
AB - Intravenous administration of Type II collagen to rats prior to immunization with Type II collagen suppresses hind paw inflammation, humoral response to Type II collagen, and the severity of the arthritic lesion. Suppression of inflammation and its severity as well as the humoral response can also be induced by the prior intravenous administration of α1 (II) CB10 a cyanogen bromide peptide derived from Type II collagen. Suppression of arthritis is disease specific; intravenous administration of either Type II collagen or α1 (II) CB10 does not have an effect on adjuvant-induced arthritis. These studies indicate that structural determinants of α1 (II) CB10 (Mr, 30,000), a peptide located near the carboxy terminus of the collagen molecule, can induce suppression and suggest that these determinants may be responsible for the suppression of arthritis when Type II collagen is administered intravenously.
UR - http://www.scopus.com/inward/record.url?scp=0021275619&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021275619&partnerID=8YFLogxK
U2 - 10.1016/0008-8749(84)90005-4
DO - 10.1016/0008-8749(84)90005-4
M3 - Article
C2 - 6467383
AN - SCOPUS:0021275619
VL - 87
SP - 357
EP - 365
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -