Suppression of strong coupling artefacts in J-spectra

Michael J. Thrippleton; Richard A.E. Edden; James Keeler

doi:10.1016/j.jmr.2005.01.012

Suppression of strong coupling artefacts in J-spectra

Michael J. Thrippleton, Richard A.E. Edden, James Keeler

Research output: Contribution to journal › Article › peer-review

Abstract

A major problem in J-resolved spectroscopy and many other experiments is the appearance of "artefacts" due to strong coupling. The signals giving rise to these artefacts follow the same coherence transfer pathways as the required signals, making it impossible to suppress them using phase cycling or pulsed field gradients. We present new methods for suppressing these artefacts, applicable to any experiment containing a J-resolved pulse sequence element, as well as to constant-time experiments.

Original language	English (US)
Pages (from-to)	97-109
Number of pages	13
Journal	Journal of Magnetic Resonance
Volume	174
Issue number	1
DOIs	https://doi.org/10.1016/j.jmr.2005.01.012
State	Published - May 2005
Externally published	Yes

Keywords

Constant time
J-resolved spectroscopy
Signal selection
Spatial variation
Strong coupling

ASJC Scopus subject areas

Biophysics
Biochemistry
Nuclear and High Energy Physics
Condensed Matter Physics

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10.1016/j.jmr.2005.01.012

Cite this

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title = "Suppression of strong coupling artefacts in J-spectra",

abstract = "A major problem in J-resolved spectroscopy and many other experiments is the appearance of {"}artefacts{"} due to strong coupling. The signals giving rise to these artefacts follow the same coherence transfer pathways as the required signals, making it impossible to suppress them using phase cycling or pulsed field gradients. We present new methods for suppressing these artefacts, applicable to any experiment containing a J-resolved pulse sequence element, as well as to constant-time experiments.",

keywords = "Constant time, J-resolved spectroscopy, Signal selection, Spatial variation, Strong coupling",

author = "Thrippleton, {Michael J.} and Edden, {Richard A.E.} and James Keeler",

note = "Funding Information: This work was supported by the EPSRC, Procter & Gamble, and the Newton Trust; R.A.E.E. thanks Eli Lilly and Company Ltd for a CASE award. We are grateful to Dr. David Neuhaus for a generous allocation of spectrometer time at the MRC LMB. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

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doi = "10.1016/j.jmr.2005.01.012",

language = "English (US)",

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AU - Thrippleton, Michael J.

AU - Edden, Richard A.E.

AU - Keeler, James

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PY - 2005/5

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N2 - A major problem in J-resolved spectroscopy and many other experiments is the appearance of "artefacts" due to strong coupling. The signals giving rise to these artefacts follow the same coherence transfer pathways as the required signals, making it impossible to suppress them using phase cycling or pulsed field gradients. We present new methods for suppressing these artefacts, applicable to any experiment containing a J-resolved pulse sequence element, as well as to constant-time experiments.

AB - A major problem in J-resolved spectroscopy and many other experiments is the appearance of "artefacts" due to strong coupling. The signals giving rise to these artefacts follow the same coherence transfer pathways as the required signals, making it impossible to suppress them using phase cycling or pulsed field gradients. We present new methods for suppressing these artefacts, applicable to any experiment containing a J-resolved pulse sequence element, as well as to constant-time experiments.

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KW - J-resolved spectroscopy

KW - Signal selection

KW - Spatial variation

KW - Strong coupling

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Suppression of strong coupling artefacts in J-spectra

Abstract

Keywords

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