Suppression of plasma cortisol in depressed patients by acute intravenous methadone infusion

P. W. Gold, I. Extein, D. Pickar

Research output: Contribution to journalArticle

Abstract

A cardinal biochemical finding in major depressive illness is activation of the hypothalamic-pituitary-adrenal (HPA) axis. This activation is manifested both by an overall increase in the daily 24-hour production rate of corticosteroids as well as disruption of the circadian pattern of corticosteroid secretion. To explore the possible interface between endorphinergic and HPA function, the authors present here a report that, represents the first study examining the effects of exogenous opiate administration on HPA function in patients with a major depressive disorder. It is proposed that the development of a methadone suppression test could be utilized to explore the possible relationship between endogenous opiate function and HPA activation in depressed patients.

Original languageEnglish (US)
Pages (from-to)862-863
Number of pages2
JournalAmerican Journal of Psychiatry
Volume137
Issue number7
StatePublished - 1980
Externally publishedYes

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Methadone
Intravenous Infusions
Hydrocortisone
Opiate Alkaloids
Adrenal Cortex Hormones
Opioid Peptides
Major Depressive Disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Suppression of plasma cortisol in depressed patients by acute intravenous methadone infusion. / Gold, P. W.; Extein, I.; Pickar, D.

In: American Journal of Psychiatry, Vol. 137, No. 7, 1980, p. 862-863.

Research output: Contribution to journalArticle

Gold, P. W. ; Extein, I. ; Pickar, D. / Suppression of plasma cortisol in depressed patients by acute intravenous methadone infusion. In: American Journal of Psychiatry. 1980 ; Vol. 137, No. 7. pp. 862-863.
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