Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate

P. C. Walsh; P. K. Siiteri

doi:10.1016/S0022-5347(17)67001-0

Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate

P. C. Walsh, P. K. Siiteri

Research output: Contribution to journal › Article › peer-review

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Abstract

Spironolactone, an inhibitor of androgen synthesis, has been administered to castrated men with metastatic carcinoma of the prostate. Plasma levels of testosterone, androstenedione and dehydroepiandrosterone were significantly decreased. These data indicated that spironolactone suppresses adrenal androgen production and suggest that it may be of benefit in the treatment of orchiectomized patients with advanced carcinoma of the prostate.

Original language	English (US)
Pages (from-to)	254-256
Number of pages	3
Journal	Journal of Urology
Volume	114
Issue number	2
DOIs	https://doi.org/10.1016/S0022-5347(17)67001-0
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Urology

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10.1016/S0022-5347(17)67001-0

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title = "Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate",

abstract = "Spironolactone, an inhibitor of androgen synthesis, has been administered to castrated men with metastatic carcinoma of the prostate. Plasma levels of testosterone, androstenedione and dehydroepiandrosterone were significantly decreased. These data indicated that spironolactone suppresses adrenal androgen production and suggest that it may be of benefit in the treatment of orchiectomized patients with advanced carcinoma of the prostate.",

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AU - Walsh, P. C.

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Y1 - 1975

N2 - Spironolactone, an inhibitor of androgen synthesis, has been administered to castrated men with metastatic carcinoma of the prostate. Plasma levels of testosterone, androstenedione and dehydroepiandrosterone were significantly decreased. These data indicated that spironolactone suppresses adrenal androgen production and suggest that it may be of benefit in the treatment of orchiectomized patients with advanced carcinoma of the prostate.

AB - Spironolactone, an inhibitor of androgen synthesis, has been administered to castrated men with metastatic carcinoma of the prostate. Plasma levels of testosterone, androstenedione and dehydroepiandrosterone were significantly decreased. These data indicated that spironolactone suppresses adrenal androgen production and suggest that it may be of benefit in the treatment of orchiectomized patients with advanced carcinoma of the prostate.

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ER -

Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate

Abstract

ASJC Scopus subject areas

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