Suppression of PCP-induced behavioral arousal in the rat by yohimbine pretreatment

Kenneth Byron, Gerald A. Young, Naim Khazan, Oksoon Hong

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The ability of yohimbine pretreatment to block PCP-induced increases in general motor behavior and head bobbing was assessed in adult female Sprague-Dawley rats. PCP-induced (5 mg/kg i.p.) increases in motor activity were significantly antagonized by yohimbine (5 mg/kg i.p.). More specific PCP-induced (5 mg/kg i.v.) head bobbing was antagonized in a dose-related manner by yohimbine (2.5 and 5 mg/kg i.p.). These data may lead to a better understanding of the mode of action of PCP.

Original languageEnglish (US)
Pages (from-to)271-273
Number of pages3
JournalEuropean Journal of Pharmacology
Issue number2
StatePublished - Nov 5 1985


  • Head bobbing
  • Motor activity
  • PCP
  • Yohimbine

ASJC Scopus subject areas

  • Pharmacology


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