Suppression of Metastasis of Rat Prostatic Cancer by Introducing Human Chromosome

Tomohiko Ichikawa, Naoki Nihei, Hiroyoshi Suzuki, Mitsuo Oshimura, Mitsuru Emi, Yusuke Nakamura, Isamu Hayata, John T. Isaacs, Jun Shimazaki

Research output: Contribution to journalArticle

Abstract

In previous allelotype analyses of human prostatic cancer specimens, allelic loss on the short arm of chromosome 8 is frequently observed. However, it is still unclear whether this allelic loss is an initial event or a later one in development of prostatic cancer. Our previous studies demonstrate that introduction of human chromosome 11 into highly metastatic rat prostatic cancer cells results in suppression of metastatic ability without suppression of the in vivo growth rate or tumorigenicity of the hybrid cells (T. Ichikawa et al. Cancer Res., 52: 3486-3490, 1992). To clarity the role of human chromosome 8 in prostatic cancer, this chromosome was introduced into highly metastatic rat prostatic cancer cells using microcell-mediated chromosome transfer. Introduction of human chromosome 8 resulted in suppression of metastatic ability of the microcell hybrids, whereas no suppression of the in vivo growth rate or tumorigenicity was observed. These results demonstrate that human chromosome 8 contains metastasis suppressor gene(s) for prostatic cancer derived from a rat. These also suggest that human chromosome 8 has an important role in development of prostatic cancer.

Original languageEnglish (US)
Pages (from-to)2299-2302
Number of pages4
JournalCancer Research
Volume54
Issue number9
StatePublished - May 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ichikawa, T., Nihei, N., Suzuki, H., Oshimura, M., Emi, M., Nakamura, Y., Hayata, I., Isaacs, J. T., & Shimazaki, J. (1994). Suppression of Metastasis of Rat Prostatic Cancer by Introducing Human Chromosome. Cancer Research, 54(9), 2299-2302.