Suppression of Lymphocyte Function After Aortic Reconstruction: Use of Nonimmunosuppressive Anesthesia

Raphael M. Keane; Andrew M. Munster; William Birmingham; Richard A. Winchurch; Thomas R. Gadacz; Calvin B. Ernst

doi:10.1001/archsurg.1982.01380330001001

Suppression of Lymphocyte Function After Aortic Reconstruction: Use of Nonimmunosuppressive Anesthesia

Raphael M. Keane, Andrew M. Munster, William Birmingham, Richard A. Winchurch, Thomas R. Gadacz, Calvin B. Ernst

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Serial estimations of lymphocyte responses to antigens and mitogens and in mixed lymphocyte culture in 13 major vascular surgical patients were carried out before and after operation, which was performed using anesthetic agents that have been shown not to depress lymphocyte function. All responses were significantly depressed up to five to eight days, and some up to nine to 11 days. Such depression, attributable to surgical trauma, may underline the vulnerability to infection of these patients who are having prostheses inserted.

Original language	English (US)
Pages (from-to)	1133-1135
Number of pages	3
Journal	Archives of surgery
Volume	117
Issue number	9
DOIs	https://doi.org/10.1001/archsurg.1982.01380330001001
State	Published - Sep 1982
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1001/archsurg.1982.01380330001001

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AU - Munster, Andrew M.

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AU - Winchurch, Richard A.

AU - Gadacz, Thomas R.

AU - Ernst, Calvin B.

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AB - Serial estimations of lymphocyte responses to antigens and mitogens and in mixed lymphocyte culture in 13 major vascular surgical patients were carried out before and after operation, which was performed using anesthetic agents that have been shown not to depress lymphocyte function. All responses were significantly depressed up to five to eight days, and some up to nine to 11 days. Such depression, attributable to surgical trauma, may underline the vulnerability to infection of these patients who are having prostheses inserted.

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Suppression of Lymphocyte Function After Aortic Reconstruction: Use of Nonimmunosuppressive Anesthesia

Abstract

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