Suppression of graft-versus-host reactions by d- and l-chloramphenicol

James J. Lipsky; Norman D. Anderson; Paul S. Lietman

doi:10.1016/0008-8749(76)90193-3

Suppression of graft-versus-host reactions by d- and l-chloramphenicol

James J. Lipsky, Norman D. Anderson, Paul S. Lietman

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

Original language	English (US)
Pages (from-to)	278-282
Number of pages	5
Journal	Cellular Immunology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(76)90193-3
State	Published - May 1976

ASJC Scopus subject areas

Immunology

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abstract = "The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.",

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year = "1976",

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AB - The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

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JF - Cellular Immunology

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ER -

Suppression of graft-versus-host reactions by d- and l-chloramphenicol

Abstract

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