Suppression of graft-versus-host reactions by d- and l-chloramphenicol

James J. Lipsky, Norman D. Anderson, Paul S. Lietman

Research output: Contribution to journalArticle

Abstract

The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalCellular Immunology
Volume23
Issue number2
DOIs
StatePublished - May 1976

    Fingerprint

ASJC Scopus subject areas

  • Immunology

Cite this