Abstract
The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.
Original language | English (US) |
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Pages (from-to) | 278-282 |
Number of pages | 5 |
Journal | Cellular Immunology |
Volume | 23 |
Issue number | 2 |
DOIs | |
State | Published - May 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology