Suppression of graft-versus-host reactions by d- and l-chloramphenicol

James J. Lipsky; Norman D. Anderson; Paul S. Lietman

doi:10.1016/0008-8749(76)90193-3

Suppression of graft-versus-host reactions by d- and l-chloramphenicol

James J. Lipsky, Norman D. Anderson, Paul S. Lietman

Research output: Contribution to journal › Article › peer-review

Abstract

The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

Original language	English (US)
Pages (from-to)	278-282
Number of pages	5
Journal	Cellular Immunology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(76)90193-3
State	Published - May 1976
Externally published	Yes

ASJC Scopus subject areas

Immunology

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title = "Suppression of graft-versus-host reactions by d- and l-chloramphenicol",

abstract = "The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.",

author = "Lipsky, {James J.} and Anderson, {Norman D.} and Lietman, {Paul S.}",

note = "Funding Information: This work was supported by NIH Grant H2 17596 and USARC Contract 17-74-C-4095. The Pharmaceutical Manufacturers Association Foundation provided a postdoctoral fellowship for J. J. L. Experiments were performed in the Alan Bernstein Laboratories of Clinical Pharmacology. We wish to thank Dr. Mildred C. Rebstock, Parke-Davis and Co., Ann Arbor, Michigan for kindly supplying L-chloramphenicol.",

year = "1976",

month = may,

doi = "10.1016/0008-8749(76)90193-3",

language = "English (US)",

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pages = "278--282",

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T1 - Suppression of graft-versus-host reactions by d- and l-chloramphenicol

AU - Lipsky, James J.

AU - Anderson, Norman D.

AU - Lietman, Paul S.

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PY - 1976/5

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N2 - The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

AB - The ability of chloramphenicol (d-threo CAP) and its optical isomer, l-threo CAP, to suppress local graft vs host reactions beneath the renal capsule of Fl hybrid rats was examined. Both isomers abrogated lymphocyte proliferation at the injection sites when blood levels were maintained near 40 μg/ml for one week by continuous intravenous infusion. Since l-threo CAP does not inhibit mitochondrial protein synthesis, it seems unlikely that the immunosuppressive effect of d-threo CAP can be attributed to this mechanism.

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JF - Cellular Immunology

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Suppression of graft-versus-host reactions by d- and l-chloramphenicol

Abstract

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