Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes

Robert O. Morton; Dawn G. Goodman; M. Eric Gershwin; Craig Derkay; Robert A. Squire; Alfred D. Steinberg

doi:10.1002/art.1780190617

Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes

Robert O. Morton, Dawn G. Goodman, M. Eric Gershwin, Craig Derkay, Robert A. Squire, Alfred D. Steinberg

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.

Original language	English (US)
Pages (from-to)	1347-1350
Number of pages	4
Journal	Arthritis & Rheumatism
Volume	19
Issue number	6
DOIs	https://doi.org/10.1002/art.1780190617
State	Published - 1976
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780190617

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title = "Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes",

abstract = "NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.",

author = "Morton, {Robert O.} and Goodman, {Dawn G.} and Gershwin, {M. Eric} and Craig Derkay and Squire, {Robert A.} and Steinberg, {Alfred D.}",

year = "1976",

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AU - Morton, Robert O.

AU - Goodman, Dawn G.

AU - Gershwin, M. Eric

AU - Derkay, Craig

AU - Squire, Robert A.

AU - Steinberg, Alfred D.

PY - 1976

Y1 - 1976

N2 - NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.

AB - NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.

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Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes

Abstract

ASJC Scopus subject areas

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