Suppression of autoimmunity in nzb mice with steroid‐sensitive x‐radiation‐sensitive syngeneic young thymocytes

Robert O. Morton, Dawn G. Goodman, M. Eric Gershwin, Craig Derkay, Robert A. Squire, Alfred D. Steinberg

Research output: Contribution to journalArticlepeer-review

Abstract

NZB mice spontaneously lose thymic regulatory or suppressor cells and subsequently develop autoimmunity and lymphoreticular hyperlasia. Treatment with 2‐week‐old syngeneic thymocytes every 2 weeks starting at 4 weeks of age suppressed these disease manifestations. The active thymocyte subpopulation was found to be sensitive to corticosteroids and X‐irradiation.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalArthritis & Rheumatism
Volume19
Issue number6
DOIs
StatePublished - 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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