Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response

Robert J. Schloesser, Husseini K. Manji, Keri Martinowich

Research output: Contribution to journalArticle

Abstract

Stress and glucocorticoids are among the strongest inhibitors of adult hippocampal neurogenesis. Despite the known role of the hippocampus in negative feedback regulation of the hypothalamo-pituitary-adrenal axis, whether the loss of hippocampal neurogenesis affects this inhibition has not been examined. Here we tested whether suppression of adult neurogenesis affected the hypothalamo-pituitary-adrenal axis response. Our results show that suppression of neurogenesis leads to a potentiated hypothalamo-pituitary-adrenal axis response after an exposure to a mild stressor. This study suggests that suppressed neurogenesis regulates the hypothalamo-pituitary-adrenal axis response.

Original languageEnglish (US)
Pages (from-to)553-557
Number of pages5
JournalNeuroreport
Volume20
Issue number6
DOIs
StatePublished - Apr 22 2009
Externally publishedYes

Keywords

  • Dentate gyrus
  • Glucocorticoid
  • Hippocampus
  • Hypothalamo-pituitary-adrenal axis
  • Neurogenesis
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

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