Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAA receptors

Dong Gen Luo, Xiong Li Yang

Research output: Contribution to journalArticle

Abstract

Modulation by Zn2+ of ON and OFF responses of transient amacrine cells driven by red- and green-sensitive cones was investigated in isolated, superfused carp retina, using intracellular recording techniques. Zn2+ selectively abolished the OFF response to red flash of the transient amacrine cells. This Zn2+ effect was mimicked by GABA application and was blocked by bicuculline, indicating the involvement of GABAA receptors. Such differential modulation was observable neither in bipolar cells nor in sustained OFF amacrine cells. It is suggested that the Zn2+ effect reported here might be due to a direct action of Zn2+ on GABAA receptors of the transient amacrine cells.

Original languageEnglish (US)
Pages (from-to)222-226
Number of pages5
JournalBrain Research
Volume958
Issue number1
DOIs
StatePublished - Dec 20 2002
Externally publishedYes

Fingerprint

Amacrine Cells
Carps
GABA-A Receptors
Zinc
Light
Bicuculline
gamma-Aminobutyric Acid
Retina

Keywords

  • Amacrine cell
  • Synaptic transmission
  • Zinc

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAA receptors. / Luo, Dong Gen; Yang, Xiong Li.

In: Brain Research, Vol. 958, No. 1, 20.12.2002, p. 222-226.

Research output: Contribution to journalArticle

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