Abstract
Modulation by Zn2+ of ON and OFF responses of transient amacrine cells driven by red- and green-sensitive cones was investigated in isolated, superfused carp retina, using intracellular recording techniques. Zn2+ selectively abolished the OFF response to red flash of the transient amacrine cells. This Zn2+ effect was mimicked by GABA application and was blocked by bicuculline, indicating the involvement of GABAA receptors. Such differential modulation was observable neither in bipolar cells nor in sustained OFF amacrine cells. It is suggested that the Zn2+ effect reported here might be due to a direct action of Zn2+ on GABAA receptors of the transient amacrine cells.
Original language | English (US) |
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Pages (from-to) | 222-226 |
Number of pages | 5 |
Journal | Brain research |
Volume | 958 |
Issue number | 1 |
DOIs | |
State | Published - Dec 20 2002 |
Keywords
- Amacrine cell
- Synaptic transmission
- Zinc
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology