TY - JOUR
T1 - Suppression and facilitation of human neural responses
AU - Schallmo, Michael Paul
AU - Kale, Alexander M.
AU - Millin, Rachel
AU - Flevaris, Anastasia V.
AU - Brkanac, Zoran
AU - Edden, Richard A.E.
AU - Bernier, Raphael A.
AU - Murray, Scott O.
N1 - Publisher Copyright:
© Schallmo et al.
PY - 2018/1/29
Y1 - 2018/1/29
N2 - Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: (1) both suppression and facilitation can emerge from a single, computational principle-divisive normalization; there is no need to invoke separate neural mechanisms, (2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and (3) suppression is not primarily driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they should not be used to infer neural inhibition.
AB - Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: (1) both suppression and facilitation can emerge from a single, computational principle-divisive normalization; there is no need to invoke separate neural mechanisms, (2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and (3) suppression is not primarily driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they should not be used to infer neural inhibition.
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U2 - 10.7554/eLife.30334
DO - 10.7554/eLife.30334
M3 - Article
C2 - 29376822
AN - SCOPUS:85042107811
SN - 2050-084X
VL - 7
JO - eLife
JF - eLife
M1 - e30334
ER -