Supply, use, and abuse of intravenous immunoglobulin

Anna Nowak-Wegrzyn, Howard M. Lederman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Intravenous immunoglobulin is used as a replacement therapy in primary immunodeficiency diseases as well as an immunomodulatory agent in a variety of autoimmune and inflammatory disorders. The mechanisms of intravenous immunoglobulin action are complex and, for some disorders, not well understood. This paper reviews the recent literature and discusses approved, new, and controversial indications for intravenous immunoglobulin therapy, with special emphasis on its mechanism of action.

Original languageEnglish (US)
Pages (from-to)533-539
Number of pages7
JournalCurrent opinion in pediatrics
Issue number6
StatePublished - 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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