Supervised method for construction of microRNA-mRNA networks: application in cardiac tissue aging dataset

Georgios N. Dimitrakopoulos; Konstantina Dimitrakopoulou; Ioannis A. Maraziotis; Kyriakos Sgarbas; Anastasios Bezerianos

doi:10.1109/EMBC.2014.6943593

Supervised method for construction of microRNA-mRNA networks: application in cardiac tissue aging dataset

Georgios N. Dimitrakopoulos, Konstantina Dimitrakopoulou, Ioannis A. Maraziotis, Kyriakos Sgarbas, Anastasios Bezerianos

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs play an important role in regulation of gene expression, but still detection of their targets remains a challenge. In this work we present a supervised regulatory network inference method with aim to identify potential target genes (mRNAs) of microRNAs. Briefly, the proposed method exploiting mRNA and microRNA expression trains Random Forests on known interactions and subsequently it is able to predict novel ones. In parallel, we incorporate different available data sources, such as Gene Ontology and ProteinProtein Interactions, to deliver biologically consistent results. Application in both benchmark data and an experiment studying aging showed robust performance.

Original language	English (US)
Pages (from-to)	318-321
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
Volume	2014
DOIs	https://doi.org/10.1109/EMBC.2014.6943593
State	Published - 2014
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Dimitrakopoulos, G. N., Dimitrakopoulou, K., Maraziotis, I. A., Sgarbas, K., & Bezerianos, A. (2014). Supervised method for construction of microRNA-mRNA networks: application in cardiac tissue aging dataset. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2014, 318-321. https://doi.org/10.1109/EMBC.2014.6943593

Supervised method for construction of microRNA-mRNA networks : application in cardiac tissue aging dataset. / Dimitrakopoulos, Georgios N.; Dimitrakopoulou, Konstantina; Maraziotis, Ioannis A.; Sgarbas, Kyriakos; Bezerianos, Anastasios.

In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, Vol. 2014, 2014, p. 318-321.

Research output: Contribution to journal › Article › peer-review

Dimitrakopoulos, GN, Dimitrakopoulou, K, Maraziotis, IA, Sgarbas, K & Bezerianos, A 2014, 'Supervised method for construction of microRNA-mRNA networks: application in cardiac tissue aging dataset', Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, vol. 2014, pp. 318-321. https://doi.org/10.1109/EMBC.2014.6943593

Dimitrakopoulos GN, Dimitrakopoulou K, Maraziotis IA, Sgarbas K, Bezerianos A. Supervised method for construction of microRNA-mRNA networks: application in cardiac tissue aging dataset. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2014;2014:318-321. https://doi.org/10.1109/EMBC.2014.6943593

Dimitrakopoulos, Georgios N. ; Dimitrakopoulou, Konstantina ; Maraziotis, Ioannis A. ; Sgarbas, Kyriakos ; Bezerianos, Anastasios. / Supervised method for construction of microRNA-mRNA networks : application in cardiac tissue aging dataset. In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2014 ; Vol. 2014. pp. 318-321.

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