Abstract
Background: During prolonged periods without glucose yeast cells acidify the extracellular environment. Results: This acid burst is derived from a mitochondrial aldehyde dehydrogenase and a cascade involving superoxide damage to the TCA cycle. Conclusion: The acid burst can condition the medium to improve cell growth. Significance: Damage from mitochondrial superoxide can be advantageous to cells during carbon starvation stress.
Original language | English (US) |
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Pages (from-to) | 4557-4566 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 7 |
DOIs | |
State | Published - Feb 15 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology