Superoxide triggers an acid burst in saccharomyces cerevisiae to condition the environment of glucose-starved cells

J. Allen Baron, Kaitlin M. Laws, Janice S. Chen, Valeria C. Culotta

Research output: Contribution to journalArticlepeer-review

Abstract

Background: During prolonged periods without glucose yeast cells acidify the extracellular environment. Results: This acid burst is derived from a mitochondrial aldehyde dehydrogenase and a cascade involving superoxide damage to the TCA cycle. Conclusion: The acid burst can condition the medium to improve cell growth. Significance: Damage from mitochondrial superoxide can be advantageous to cells during carbon starvation stress.

Original languageEnglish (US)
Pages (from-to)4557-4566
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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