Superoxide triggers an acid burst in saccharomyces cerevisiae to condition the environment of glucose-starved cells

J. Allen Baron; Kaitlin M. Laws; Janice S. Chen; Valeria C. Culotta

doi:10.1074/jbc.M112.409508

Superoxide triggers an acid burst in saccharomyces cerevisiae to condition the environment of glucose-starved cells

J. Allen Baron, Kaitlin M. Laws, Janice S. Chen, Valeria C. Culotta

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Background: During prolonged periods without glucose yeast cells acidify the extracellular environment. Results: This acid burst is derived from a mitochondrial aldehyde dehydrogenase and a cascade involving superoxide damage to the TCA cycle. Conclusion: The acid burst can condition the medium to improve cell growth. Significance: Damage from mitochondrial superoxide can be advantageous to cells during carbon starvation stress.

Original language	English (US)
Pages (from-to)	4557-4566
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.409508
State	Published - Feb 15 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Superoxide triggers an acid burst in saccharomyces cerevisiae to condition the environment of glucose-starved cells

Abstract

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