TY - JOUR
T1 - Superoxide radical trapping and spin adduct decay of 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO)
T2 - Kinetics and theoretical analysis
AU - Villamena, Frederick A.
AU - Zweier, Jay L.
PY - 2002
Y1 - 2002
N2 - Spin-trapping of oxygen-centered radicals such as superoxide radical is increasingly becoming important in the study of biological oxidations. Superoxide spin-trapping and decay kinetics in aqueous media of the new solid nitrone 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO) are reported and compared to those of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO). Superoxide spin-trapping by BocMPO is significantly slower than that by DEPMPO and DMPO, and the half-life of BocMPO-superoxide adduct is shorter than that of DEPMPO-superoxide adduct. The BocMPO spin-trapping ability and stability of its superoxide adducts are rationalized based on theoretical calculations.
AB - Spin-trapping of oxygen-centered radicals such as superoxide radical is increasingly becoming important in the study of biological oxidations. Superoxide spin-trapping and decay kinetics in aqueous media of the new solid nitrone 5-tert-butoxycarbonyl-5-methyl-1-pyrroline N-oxide (BocMPO) are reported and compared to those of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO). Superoxide spin-trapping by BocMPO is significantly slower than that by DEPMPO and DMPO, and the half-life of BocMPO-superoxide adduct is shorter than that of DEPMPO-superoxide adduct. The BocMPO spin-trapping ability and stability of its superoxide adducts are rationalized based on theoretical calculations.
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M3 - Article
AN - SCOPUS:0036019831
SN - 1470-1820
SP - 1340
EP - 1344
JO - Journal of the Chemical Society, Perkin Transactions 2
JF - Journal of the Chemical Society, Perkin Transactions 2
IS - 7
ER -