Superior mesenteric artery margin of posttherapy pancreaticoduodenectomy and prognosis in patients with pancreatic ductal adenocarcinoma

Li Liu, Matthew H. Katz, Sun M. Lee, Laurice K. Fischer, Laura Prakash, Nathan Parker, Hua Wang, Gauri R. Varadhachary, Robert A. Wolff, Jeffrey E. Lee, Peter W. Pisters, Anirban Maitra, Jason B. Fleming, Jeannelyn Estrella, Asif Rashid, Huamin Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Negative-margin resection is crucial to favorable prognosis in patients with pancreatic ductal adenocarcinoma. However, the definition of a negative superior mesenteric artery margin (SMAM) varies. The College of American Pathologists defines positive SMAM as the presence of tumor cells at the margin, whereas the European protocol is based on a 1mm clearance. In this study, we examined the prognostic significance of the SMAM distance in 411 consecutive pancreatic ductal adenocarcinoma patients who completed neoadjuvant therapy and pancreaticoduodenectomy. Per College of American Pathologists criteria, 32 (7.8%) had positive margins, and 379 (92.2%) had negative margins. Among margin-negative group, SMAM was ≤ 1, 1.0 to 5.0, and > 5.0mm in 66, 145, and 168 patients, respectively. There was no difference in either diseasefree survival (DFS) or overall survival (OS) between the positive-margin group and SMAM ≤ 1mm (P> 0.05). However, patients with SMAM 1.0 to 5.0mm had better OS than those with positive margins or SMAM ≤ 1mm (P=0.02). Patients with SMAM> 5.0mm had better DFS and OS than those with SMAM 1.0 to 5.0mm and those with positive margins or SMAM ≤ 1mm(P <0.01). By multivariate analysis, the SMAM distance, tumor differentiation, lymph node metastasis, and histopathologic tumor response grade were independent prognostic factors for both DFS and OS. SMAM distance correlated with lower ypT and AJCC stages, smaller tumor size, better histopathologic tumor response grade, fewer lymph node metastases, and recurrences (P <0.05). Thus our results strongly support use of SMAM> 1mm for R0 resection in posttherapy pancreaticoduodenectomy specimens.

Original languageEnglish (US)
Pages (from-to)1395-1403
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume39
Issue number10
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • Histopathologic tumor response grade
  • Pancreatic ductal adenocarcinoma
  • Prognosis
  • Superior mesenteric artery margin
  • Survival

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

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