TY - JOUR
T1 - Superior mesenteric artery margin of posttherapy pancreaticoduodenectomy and prognosis in patients with pancreatic ductal adenocarcinoma
AU - Liu, Li
AU - Katz, Matthew H.
AU - Lee, Sun M.
AU - Fischer, Laurice K.
AU - Prakash, Laura
AU - Parker, Nathan
AU - Wang, Hua
AU - Varadhachary, Gauri R.
AU - Wolff, Robert A.
AU - Lee, Jeffrey E.
AU - Pisters, Peter W.
AU - Maitra, Anirban
AU - Fleming, Jason B.
AU - Estrella, Jeannelyn
AU - Rashid, Asif
AU - Wang, Huamin
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Negative-margin resection is crucial to favorable prognosis in patients with pancreatic ductal adenocarcinoma. However, the definition of a negative superior mesenteric artery margin (SMAM) varies. The College of American Pathologists defines positive SMAM as the presence of tumor cells at the margin, whereas the European protocol is based on a 1mm clearance. In this study, we examined the prognostic significance of the SMAM distance in 411 consecutive pancreatic ductal adenocarcinoma patients who completed neoadjuvant therapy and pancreaticoduodenectomy. Per College of American Pathologists criteria, 32 (7.8%) had positive margins, and 379 (92.2%) had negative margins. Among margin-negative group, SMAM was ≤ 1, 1.0 to 5.0, and > 5.0mm in 66, 145, and 168 patients, respectively. There was no difference in either diseasefree survival (DFS) or overall survival (OS) between the positive-margin group and SMAM ≤ 1mm (P> 0.05). However, patients with SMAM 1.0 to 5.0mm had better OS than those with positive margins or SMAM ≤ 1mm (P=0.02). Patients with SMAM> 5.0mm had better DFS and OS than those with SMAM 1.0 to 5.0mm and those with positive margins or SMAM ≤ 1mm(P <0.01). By multivariate analysis, the SMAM distance, tumor differentiation, lymph node metastasis, and histopathologic tumor response grade were independent prognostic factors for both DFS and OS. SMAM distance correlated with lower ypT and AJCC stages, smaller tumor size, better histopathologic tumor response grade, fewer lymph node metastases, and recurrences (P <0.05). Thus our results strongly support use of SMAM> 1mm for R0 resection in posttherapy pancreaticoduodenectomy specimens.
AB - Negative-margin resection is crucial to favorable prognosis in patients with pancreatic ductal adenocarcinoma. However, the definition of a negative superior mesenteric artery margin (SMAM) varies. The College of American Pathologists defines positive SMAM as the presence of tumor cells at the margin, whereas the European protocol is based on a 1mm clearance. In this study, we examined the prognostic significance of the SMAM distance in 411 consecutive pancreatic ductal adenocarcinoma patients who completed neoadjuvant therapy and pancreaticoduodenectomy. Per College of American Pathologists criteria, 32 (7.8%) had positive margins, and 379 (92.2%) had negative margins. Among margin-negative group, SMAM was ≤ 1, 1.0 to 5.0, and > 5.0mm in 66, 145, and 168 patients, respectively. There was no difference in either diseasefree survival (DFS) or overall survival (OS) between the positive-margin group and SMAM ≤ 1mm (P> 0.05). However, patients with SMAM 1.0 to 5.0mm had better OS than those with positive margins or SMAM ≤ 1mm (P=0.02). Patients with SMAM> 5.0mm had better DFS and OS than those with SMAM 1.0 to 5.0mm and those with positive margins or SMAM ≤ 1mm(P <0.01). By multivariate analysis, the SMAM distance, tumor differentiation, lymph node metastasis, and histopathologic tumor response grade were independent prognostic factors for both DFS and OS. SMAM distance correlated with lower ypT and AJCC stages, smaller tumor size, better histopathologic tumor response grade, fewer lymph node metastases, and recurrences (P <0.05). Thus our results strongly support use of SMAM> 1mm for R0 resection in posttherapy pancreaticoduodenectomy specimens.
KW - Histopathologic tumor response grade
KW - Pancreatic ductal adenocarcinoma
KW - Prognosis
KW - Superior mesenteric artery margin
KW - Survival
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M3 - Article
C2 - 26200098
AN - SCOPUS:84941773372
SN - 0147-5185
VL - 39
SP - 1395
EP - 1403
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 10
ER -