Superficial siderosis associated with multiple cavernous malformations: Report of three cases

Khan W. Li, Raymond I. Haroun, Richard E. Clatterbuck, Kieran Murphy, Daniele Rigamonti

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE AND IMPORTANCE: Superficial siderosis is a rare but potentially devastating syndrome caused by recurrent subarachnoid hemorrhage. We present three cases of superficial siderosis associated with multiple cavernous malformations, and we review previous reports of superficial siderosis attributable to vascular malformations. CLINICAL PRESENTATION: Patients most commonly present with progressive sensorineural hearing loss, cerebellar ataxia, and pyramidal signs. Magnetic resonance imaging diagnosis may precede symptom development, however. In two of our cases, superficial siderosis was identified on magnetic resonance imaging scans in the absence of clinical symptoms. INTERVENTION: Magnetic resonance imaging studies revealed hemosiderin deposition, characteristic of superficial siderosis, and multiple cavernous malformations in all three cases. Surgical intervention was not pursued. CONCLUSION: We conclude that patients with multiple cavernous malformations and those with perisubarachnoid lesions are at risk for the development of superficial siderosis. Clinicians should recognize the radiographic appearance of superficial siderosis and its clinical presentation in patients with vascular malformations.

Original languageEnglish (US)
Pages (from-to)1147-1151
Number of pages5
JournalNeurosurgery
Volume48
Issue number5
StatePublished - May 3 2001

Keywords

  • Cavernous malformation
  • Subarachnoid hemorrhage
  • Superficial siderosis
  • Vascular malformation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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