Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III

Mary M. McDermott, Kiang Liu, James Carr, Michael H. Criqui, Lu Tian, Debiao Li, Luigi Ferrucci, Jack M. Guralnik, Christopher M. Kramer, Chun Yuan, Melina Kibbe, William H. Pearce, Jarett Berry, Walter McCarthy, Yihua Liao, Dongxiang Xu, Jennifer Orozco, Timothy J. Carroll

Research output: Contribution to journalArticle

Abstract

Background-The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). Methods and Results-Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalCirculation: Cardiovascular Imaging
Volume4
Issue number3
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Ankle Brachial Index
Peripheral Arterial Disease
Femoral Artery
Walking
Leg
Arteries
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Lower Extremity
Magnetic Resonance Spectroscopy
Smoking
Cholesterol

Keywords

  • Atherosclerosis
  • MRI
  • Peripheral vascular disease
  • Plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III. / McDermott, Mary M.; Liu, Kiang; Carr, James; Criqui, Michael H.; Tian, Lu; Li, Debiao; Ferrucci, Luigi; Guralnik, Jack M.; Kramer, Christopher M.; Yuan, Chun; Kibbe, Melina; Pearce, William H.; Berry, Jarett; McCarthy, Walter; Liao, Yihua; Xu, Dongxiang; Orozco, Jennifer; Carroll, Timothy J.

In: Circulation: Cardiovascular Imaging, Vol. 4, No. 3, 05.2011, p. 246-252.

Research output: Contribution to journalArticle

McDermott, MM, Liu, K, Carr, J, Criqui, MH, Tian, L, Li, D, Ferrucci, L, Guralnik, JM, Kramer, CM, Yuan, C, Kibbe, M, Pearce, WH, Berry, J, McCarthy, W, Liao, Y, Xu, D, Orozco, J & Carroll, TJ 2011, 'Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III', Circulation: Cardiovascular Imaging, vol. 4, no. 3, pp. 246-252. https://doi.org/10.1161/CIRCIMAGING.110.962183
McDermott, Mary M. ; Liu, Kiang ; Carr, James ; Criqui, Michael H. ; Tian, Lu ; Li, Debiao ; Ferrucci, Luigi ; Guralnik, Jack M. ; Kramer, Christopher M. ; Yuan, Chun ; Kibbe, Melina ; Pearce, William H. ; Berry, Jarett ; McCarthy, Walter ; Liao, Yihua ; Xu, Dongxiang ; Orozco, Jennifer ; Carroll, Timothy J. / Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III. In: Circulation: Cardiovascular Imaging. 2011 ; Vol. 4, No. 3. pp. 246-252.
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