Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III

Mary M. McDermott; Kiang Liu; James Carr; Michael H. Criqui; Lu Tian; Debiao Li; Luigi Ferrucci; Jack M. Guralnik; Christopher M. Kramer; Chun Yuan; Melina Kibbe; William H. Pearce; Jarett Berry; Walter McCarthy; Yihua Liao; Dongxiang Xu; Jennifer Orozco; Timothy J. Carroll

doi:10.1161/CIRCIMAGING.110.962183

Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III

Mary M. McDermott, Kiang Liu, James Carr, Michael H. Criqui, Lu Tian, Debiao Li, Luigi Ferrucci, Jack M. Guralnik, Christopher M. Kramer, Chun Yuan, Melina Kibbe, William H. Pearce, Jarett Berry, Walter McCarthy, Yihua Liao, Dongxiang Xu, Jennifer Orozco, Timothy J. Carroll

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background-The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). Methods and Results-Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI

Original language	English (US)
Pages (from-to)	246-252
Number of pages	7
Journal	Circulation: Cardiovascular Imaging
Volume	4
Issue number	3
DOIs	https://doi.org/10.1161/CIRCIMAGING.110.962183
State	Published - May 2011
Externally published	Yes

Keywords

Atherosclerosis
MRI
Peripheral vascular disease
Plaque

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging
General Medicine

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10.1161/CIRCIMAGING.110.962183

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McDermott, M. M., Liu, K., Carr, J., Criqui, M. H., Tian, L., Li, D., Ferrucci, L., Guralnik, J. M., Kramer, C. M., Yuan, C., Kibbe, M., Pearce, W. H., Berry, J., McCarthy, W., Liao, Y., Xu, D., Orozco, J., & Carroll, T. J. (2011). Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III. Circulation: Cardiovascular Imaging, 4(3), 246-252. https://doi.org/10.1161/CIRCIMAGING.110.962183

McDermott, MM, Liu, K, Carr, J, Criqui, MH, Tian, L, Li, D, Ferrucci, L, Guralnik, JM, Kramer, CM, Yuan, C, Kibbe, M, Pearce, WH, Berry, J, McCarthy, W, Liao, Y, Xu, D, Orozco, J & Carroll, TJ 2011, 'Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III', Circulation: Cardiovascular Imaging, vol. 4, no. 3, pp. 246-252. https://doi.org/10.1161/CIRCIMAGING.110.962183

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title = "Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III",

abstract = "Background-The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). Methods and Results-Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI ",

keywords = "Atherosclerosis, MRI, Peripheral vascular disease, Plaque",

author = "McDermott, {Mary M.} and Kiang Liu and James Carr and Criqui, {Michael H.} and Lu Tian and Debiao Li and Luigi Ferrucci and Guralnik, {Jack M.} and Kramer, {Christopher M.} and Chun Yuan and Melina Kibbe and Pearce, {William H.} and Jarett Berry and Walter McCarthy and Yihua Liao and Dongxiang Xu and Jennifer Orozco and Carroll, {Timothy J.}",

year = "2011",

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doi = "10.1161/CIRCIMAGING.110.962183",

language = "English (US)",

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pages = "246--252",

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AU - McDermott, Mary M.

AU - Liu, Kiang

AU - Carr, James

AU - Criqui, Michael H.

AU - Tian, Lu

AU - Li, Debiao

AU - Ferrucci, Luigi

AU - Guralnik, Jack M.

AU - Kramer, Christopher M.

AU - Yuan, Chun

AU - Kibbe, Melina

AU - Pearce, William H.

AU - Berry, Jarett

AU - McCarthy, Walter

AU - Liao, Yihua

AU - Xu, Dongxiang

AU - Orozco, Jennifer

AU - Carroll, Timothy J.

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N2 - Background-The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). Methods and Results-Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI

AB - Background-The clinical significance of magnetic resonance-imaged plaque characteristics in the superficial femoral artery (SFA) is not well established. We studied associations of the ankle-brachial index (ABI) and leg symptoms with MRI-measured plaque area and percent lumen area in the SFA in participants with and without lower-extremity peripheral arterial disease (PAD). Methods and Results-Four hundred twenty-seven participants (393 with PAD) underwent plaque imaging of the first 30 mm of the SFA. Twelve 2.5-mm cross-sectional images of the SFA were obtained. Outcomes were normalized plaque area, adjusted for artery size (0 to 1 scale, 1=greatest plaque), and lumen area, expressed as a percent of the total artery area. Adjusting for age, sex, race, smoking, statins, cholesterol, and other covariates, lower ABI values were associated with higher normalized mean plaque area (ABI

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Superficial femoral artery plaque, the ankle-brachial index, and leg symptoms in peripheral arterial disease the walking and leg circulation study (WALCS) III

Abstract

Keywords

ASJC Scopus subject areas

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