Supercoiled loops and the organization of replication and transcription in eukaryotes

Barbara A. Zehnbauer, Bert Vogelstein

Research output: Contribution to journalReview article

Abstract

The nuclear DNA of eukaryotes is organized into a series of loops each topologically anchored by elements of the nuclear matrix. Evidence is reviewed which indicates that the anchorage points of the loops are formed by transcriptionally active genes and that individual loops function as replicons. The data suggests a specific model for coupling of DNA replication and transcription in eukaryotes.

Original languageEnglish (US)
Pages (from-to)52-54
Number of pages3
JournalBioEssays
Volume2
Issue number2
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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