Super-achromatic optical coherence tomography capsule for ultrahigh-resolution imaging of esophagus

Kaiyan Li, Wenxuan Liang, Jessica Mavadia-Shukla, Hyeon Cheol Park, Dawei Li, Wu Yuan, Suiren Wan, Xingde Li

Research output: Contribution to journalArticle

Abstract

Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1300 nm wavelength region with a suboptimal axial resolution limited to 8-20 μm. In this paper, we present the first ultrahigh-resolution tethered OCT capsule operating at 800 nm and offering about 3- to 4-fold improvement of axial resolution (plus enhanced imaging contrast). The capsule uses diffractive optics to manage chromatic aberration over a full ~200 nm spectral bandwidth centering around 830 nm, enabling to achieve super-achromaticity and an axial resolution of ~2.6 μm in air. The performance of the OCT capsule is demonstrated by volumetric imaging of swine esophagus ex vivo and sheep esophagus in vivo, where fine anatomic structures including the sub-epithelial layers are clearly identified. The ultrahigh resolution and excellent imaging contrast at 800 nm of the tethered capsule suggest the potential of the technology as an enabling tool for surveillance of early esophageal diseases on awake patients without the need for sedation.

Original languageEnglish (US)
Article numbere201800205
JournalJournal of biophotonics
Volume12
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • capsule
  • endoscopic optical coherence tomography
  • esophagus
  • super-achromatic
  • ultrahigh resolution

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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