99Tcm-MDP uptake by lymph nodes following tracer infiltration: Clinical and laboratory evaluation

Jerold W. Wallis, Susan Fisher, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalNuclear Medicine Communications
Volume8
Issue number5
StatePublished - 1987
Externally publishedYes

Fingerprint

Lymph Nodes
Injections
Diphosphonates
Thigh
Neoplasm Metastasis
Bone and Bones
Liver
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

99Tcm-MDP uptake by lymph nodes following tracer infiltration : Clinical and laboratory evaluation. / Wallis, Jerold W.; Fisher, Susan; Wahl, Richard L.

In: Nuclear Medicine Communications, Vol. 8, No. 5, 1987, p. 357-363.

Research output: Contribution to journalArticle

Wallis, Jerold W. ; Fisher, Susan ; Wahl, Richard L. / 99Tcm-MDP uptake by lymph nodes following tracer infiltration : Clinical and laboratory evaluation. In: Nuclear Medicine Communications. 1987 ; Vol. 8, No. 5. pp. 357-363.
@article{8413477dcb6640768d004ac517c42ef2,
title = "99Tcm-MDP uptake by lymph nodes following tracer infiltration: Clinical and laboratory evaluation",
abstract = "Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.",
author = "Wallis, {Jerold W.} and Susan Fisher and Wahl, {Richard L.}",
year = "1987",
language = "English (US)",
volume = "8",
pages = "357--363",
journal = "Nuclear Medicine Communications",
issn = "0143-3636",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - 99Tcm-MDP uptake by lymph nodes following tracer infiltration

T2 - Clinical and laboratory evaluation

AU - Wallis, Jerold W.

AU - Fisher, Susan

AU - Wahl, Richard L.

PY - 1987

Y1 - 1987

N2 - Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.

AB - Uptake of bone scanning agents in non-osseous sites has been described in a variety of pathologic conditions including tumor metastases. We have seen several patients in which such uptake was proximal and ipsilateral to the injection site of99Tcm-rnethylene diphos- phonate, apparently in normal lymph nodes. To further investigate this phenomenon, it was studied in a rat model. Activity in popliteal nodes ipsilateral to the injection site was over 60-fold greater in the animals that received subcutaneous (s.q.) footpad injection compared to femoral IV injection. Ipsilateral popliteal node activity in the s.q. group was 159 times that of contralateral popliteal nodes, with an ipsilateral node to liver ratio of 184:1. In summary, dramatically increased uptake of99Tcm-MDP in normal lymph nodes ipsilateral and proximal to an extravasated injection has been demonstrated. An awareness of this phenomenon in the clinical setting can avoid confusion with pathologic forms of soft tissue uptake.

UR - http://www.scopus.com/inward/record.url?scp=0023159012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023159012&partnerID=8YFLogxK

M3 - Article

C2 - 3684101

AN - SCOPUS:0023159012

VL - 8

SP - 357

EP - 363

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 5

ER -