99mTc-pyrophosphate imaging in experimental mesenteric infarction: Relationship of tracer uptake to the degree of ischemic injury

K. H. Barth, P. O. Alderson, J. D. Strandberg

Research output: Contribution to journalArticlepeer-review

Abstract

Four-hour ballon occlusion of the cranial mesenteric artery in 13 dogs produced a spectrum of widespread ischemic injury to the small bowel ranging from superficial mucosal infarction to transmural infarction. Twenty-four hours after the beginning of balloon occlusion, 15 mCi of 99mTc-pyrophosphate was injected into the cranial mesenteric artery in 8 dogs and into a peripheral vein in 5. Gamma camera imaging of the abdomen followed three hours later. Four of 8 dogs injected intra-arterially showed positive images with full-thickness mucosal or transmural infarction. The 4 intravenously injected dogs with positive images had transmural infarction. Only minimal ischemic injury with superficial mucosal infarction was found in the 5 dogs with negative images. Tracer uptake per gram infarcted tissue was highest after intra-arterial injection. It was concluded that 99mTc-pyrophosphate allows external imaging of extensive intestinal infarctions after both intra-arterial and intravenous injection.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalRADIOLOGY
Volume129
Issue number2
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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