TY - JOUR
T1 - 90Y radioembolization of colorectal hepatic metastases using glass microspheres
T2 - Safety and survival outcomes from a 531-patient multicenter study
AU - Hickey, Ryan
AU - Lewandowski, Robert J.
AU - Prudhomme, Totianna
AU - Ehrenwald, Eduardo
AU - Baigorri, Brian
AU - Critchfield, Jeffrey
AU - Kallini, Joseph
AU - Gabr, Ahmed
AU - Gorodetski, Boris
AU - Geschwind, Jean Francois
AU - Abbott, Andrea
AU - Shridhar, Ravi
AU - White, Sarah B.
AU - Rilling, William S.
AU - Boyer, Brendan
AU - Kauffman, Shannon
AU - Kwan, Sharon
AU - Padia, Siddarth A.
AU - Gates, Vanessa L.
AU - Mulcahy, Mary
AU - Kircher, Sheetal
AU - Nimeiri, Halla
AU - Benson, Al B.
AU - Salem, Riad
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Hepatic metastases of colorectal carcinoma are a leading cause of cancer-related mortality. Most colorectal liver metastases become refractory to chemotherapy and biologic agents, at which point the median overall survival declines to 4 5 mo. Radioembolization with 90Y has been used in the salvage setting with favorable outcomes. This study reports the survival and safety outcomes of 531 patients treated with glass-based 90Y microspheres at 8 institutions, making it the largest 90Y study for patients with colorectal liver metastases. Methods: Data were retrospectively compiled from 8 institutions for all 90Y glass microsphere treatments for colorectal liver metastases. Exposure to chemotherapeutic or biologic agents, prior liver therapies, biochemical parameters before and after treatment, radiation dosimetry, and complications were recorded. Uni- and multivariate analyses for predictors of survival were performed. Survival outcomes and clinical or biochemical adverse events were recorded. Results: In total, 531 patients received 90Y radioembolization for colorectal liver metastases. The most common clinical adverse events were fatigue (55%), abdominal pain (34%), and nausea (19%). Grade 3 or 4 hyperbilirubinemia occurred in 13%of patients at any time. The median overall survival from the first 90Y treatment was 10.6 mo (95% confidence interval, 8.8 12.4). Performance status, no more than 25% tumor burden, no extrahepatic metastases, albumin greater than 3 g/dL, and receipt of no more than 2 chemotherapeutic agents independently predicted better survival outcomes. Conclusion: This multiinstitutional review of a large cohort of patients with colorectal liver metastases treated with 90Y radioembolization using glass microspheres has demonstrated promising survival outcomes with low toxicity and low side effects. The outcomes were reproducible and consistent with prior reports of radioembolization. 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
AB - Hepatic metastases of colorectal carcinoma are a leading cause of cancer-related mortality. Most colorectal liver metastases become refractory to chemotherapy and biologic agents, at which point the median overall survival declines to 4 5 mo. Radioembolization with 90Y has been used in the salvage setting with favorable outcomes. This study reports the survival and safety outcomes of 531 patients treated with glass-based 90Y microspheres at 8 institutions, making it the largest 90Y study for patients with colorectal liver metastases. Methods: Data were retrospectively compiled from 8 institutions for all 90Y glass microsphere treatments for colorectal liver metastases. Exposure to chemotherapeutic or biologic agents, prior liver therapies, biochemical parameters before and after treatment, radiation dosimetry, and complications were recorded. Uni- and multivariate analyses for predictors of survival were performed. Survival outcomes and clinical or biochemical adverse events were recorded. Results: In total, 531 patients received 90Y radioembolization for colorectal liver metastases. The most common clinical adverse events were fatigue (55%), abdominal pain (34%), and nausea (19%). Grade 3 or 4 hyperbilirubinemia occurred in 13%of patients at any time. The median overall survival from the first 90Y treatment was 10.6 mo (95% confidence interval, 8.8 12.4). Performance status, no more than 25% tumor burden, no extrahepatic metastases, albumin greater than 3 g/dL, and receipt of no more than 2 chemotherapeutic agents independently predicted better survival outcomes. Conclusion: This multiinstitutional review of a large cohort of patients with colorectal liver metastases treated with 90Y radioembolization using glass microspheres has demonstrated promising survival outcomes with low toxicity and low side effects. The outcomes were reproducible and consistent with prior reports of radioembolization. 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc.
KW - Colorectal metastases
KW - Radioembolization
KW - Survival
KW - Y
UR - http://www.scopus.com/inward/record.url?scp=84966775474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966775474&partnerID=8YFLogxK
U2 - 10.2967/jnumed.115.166082
DO - 10.2967/jnumed.115.166082
M3 - Article
C2 - 26635340
AN - SCOPUS:84966775474
SN - 0161-5505
VL - 57
SP - 665
EP - 671
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 5
ER -