89Zr-radiolabeled trastuzumab imaging in orthotopic and metastatic breast tumors

Albert J. Chang, Ravindra DeSilva, Sandeep Jain, Kimberley Lears, Buck Rogers, Suzanne Lapi

Research output: Contribution to journalArticlepeer-review

Abstract

The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases. Trastuzumab, an anti-HER2 monoclonal antibody, is used for the treatment of HER2 positive breast cancer and clinical efficacy of this agent is dependent on HER2 expression. Targeted PET imaging of HER2 with radiolabeled trastuzumab may be used to determine HER2 expression levels and guide therapy selection. The purpose of the current study was to evaluate a facile 89Zr-trastuzumab preparation method that can be efficiently applied for clinical grade production. Also, relative HER2 expression levels in orthotopic and metastatic breast cancer models were assessed by PET imaging using the 89Zr-trastuzumab produced by this simpler method.

Original languageEnglish (US)
Pages (from-to)79-93
Number of pages15
JournalPharmaceuticals
Volume5
Issue number1
DOIs
StatePublished - Jan 5 2012

Keywords

  • HER2
  • ImmunoPET
  • PET

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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