68Ga-DOTATATE PET: Temporal variation of maximum standardized uptake value in normal tissues and neuroendocrine tumours

George Barberio Coura-Filho, Ana A.F.O. Hoff, Paulo S. Duarte, Carlos A. Buchpiguel, Anders Josefsson, Robert F. Hobbs, George Sgouros, Marcelo T. Sapienza

Research output: Contribution to journalArticle

Abstract

Objectives Higher affinity of 68Ga compounds to somatostatin receptors (SSTRs) and PET better image resolution increased interest in 68Ga-labelled somatostatin analogs in the management of neuroendocrine tumours (NETs). This study aimed to evaluate the maximum standardized uptake value (SUVmax) variation in sequential somatostatin analogs-PET in NET patients and identify optimal tumour detection and characterization imaging time. Methods Patients with histological or biochemical NET diagnosis performed two to three PET/computed tomography (CT) scans after intravenous injection of 68Ga-DOTATATE: Early PET [EarlyPET: <15 minutes postinjection (p.i.)], diagnostic PET (DiagPET: 45-90 minutes p.i.) and delayed PET (DelayPE: 90-240 minutes p.i.). Up to five tumour sites and normal tissues had SUVmax determined. Time-SUVmax curves were created for the target lesions and normal organs. Ratios between tumour and liver SUVmax (SUVTU/Liver) and tumour/blood pool (SUVTU/BP) were also calculated. Results Twenty-nine patients were included, 16 female, mean age of 46.5 ± 14.3 years. Average administered activity was 129.5 ± 29.6 MBq. Kidneys SUVmax was higher in EarlyPET compared with DiagPET (P = 0.04) and DelayPET showed higher SUVmax compared with DiagPET for normal liver, pancreas and kidneys (P = 0.02). No differences were noted between EarlyPET, DiagPET and DelayPET in tumour SUVmax (P > 0.05). SUVTU/Liver and SUVTU/BP did not change between EarlyPET and DiagPET, with a slight decrease in DelayPET. Conclusion Stability in tumour SUVmax values measured at different intervals independently of tumour location, as also in normal tissues as kidneys and liver suggest that a more flexible imaging protocol may be adopted.

Original languageEnglish (US)
Pages (from-to)920-926
Number of pages7
JournalNuclear medicine communications
Volume40
Issue number9
DOIs
StatePublished - Sep 1 2019

Keywords

  • PET/computed tomography
  • biokinetics
  • gallium-68-DOTA
  • neuroendocrine tumours

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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