The present study investigated the effects of damage to the basal forebrain cholinergic system upon [3H]ketanserin binding in the neocortex and hippocampus of monkeys. [3H]Ketanserin specifically binds to serotonin type-2 receptor sites. Lesions were placed in the medial septal area, nucleus basalis, or both regions. Ten months later, [3H]ketanserin binding was increased in the neocortex, but not in the hippocampus, while levels of choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, EC 184.108.40.206) activity decreased in the neocortex and hippocampus. Changes in the levels of choline acetyltransferase and [3H]ketanserin binding were correlated significantly in the neocortex (r = -0.64, P < 0.025), but not in the hippocampus. The data suggest that degeneration of the basal forebrain cholinergic system may alter serotonergic function in the neocortex.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Cell Biology