3H-spiroperidol labels dopamine receptors in pituitary and brain

Ian Creese, Robert Schneider, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

3H-Spiroperidol of high specific radioactivity labels dopamine receptors in membranes of bovine caudate nucleuse an anteroir pituitary. The saturation and kinetic properties of 3H-spiroperidol binding are similar in the two tissues. In both caudate and pituitary 3H-spiroperidol displays very high affinity with a dissociation constant of 0.2-0.3 nM. The relative potencies of numerous dopamine agonist and antagonists in competing for 3H-spiroperidol binding are closely similar in anterior pituitary and caudate.

Original languageEnglish (US)
Pages (from-to)377-381
Number of pages5
JournalEuropean Journal of Pharmacology
Volume46
Issue number4
DOIs
StatePublished - Dec 15 1977

Keywords

  • Anterior pituitary
  • Caudate nucleus
  • Dopamine receptor
  • H-Spiroperidol
  • Neuroleptic

ASJC Scopus subject areas

  • Pharmacology

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