3H-paroxetine binding in brains of alcoholics

Han Tong Chen, Manuel F. Casanova, Joel E. Kleinman, Mark Zito, David Goldman, Markku Linnoila

Research output: Contribution to journalArticle

Abstract

High affinity 3H-paroxetine binding was studied in human frontal cortex and hippocampus obtained from normal controls and alcoholics. On the basis of Scatchard analyses, a significant decrease in the maximal number of binding sites (Bmax) was found in the hippocampus of alcoholics (n=8) as compared with that of controls (n = 10) (mean±SD=63±35 vs. 114±70 fmoles/mg protein). There was no significant difference in the dissociation constants (Kd) between the two groups. The presumed effect of chronic alcohol abuse on 3H-paroxetine binding may be region-specific since no significant difference in either Bmax or Kd for 3H-paroxetine binding was found in the frontal cortex between normal controls and alcoholics. No significant correlation of 3H-paroxetine binding with age or postmortem interval was observed. The decrease in 3H-paroxetine binding in the hippocampus of alcoholics is probably indicative of reduced density of serotonergic nerve terminals either as a preexisting condition or as a result of neuronal damage caused by ethanol or the sequelae of alcoholism, such as nutritional deficiencies.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalPsychiatry research
Volume38
Issue number3
DOIs
StatePublished - Sep 1991
Externally publishedYes

Keywords

  • Paroxetine binding
  • alcoholics
  • human brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Chen, H. T., Casanova, M. F., Kleinman, J. E., Zito, M., Goldman, D., & Linnoila, M. (1991). 3H-paroxetine binding in brains of alcoholics. Psychiatry research, 38(3), 293-299. https://doi.org/10.1016/0165-1781(91)90019-L