1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning

Yu Guo, Zhongfeng Li, Xinfeng Liu, Xiaolan Su, Yijie Li, Jiajie Zhu, Yilin Song, Ping Zhang, Jiande D.Z. Chen, Ruhan Wei, Jianqin Yang, Wei Wei

Research output: Research - peer-reviewArticle

Abstract

1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN). After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls. Based on 1H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles. According to the key metabolites determined by OPLS-DA, alterations in energy metabolism, stress-related metabolism, and gut microbiota were found in FD model rats after stress stimulation, and these alterations were restored to normal after WKN administration. This study may provide new insights into the relationship between FD and psychological stress and assist in research into the metabolic mechanisms involved in Chinese medicine.

LanguageEnglish (US)
Article number4039425
JournalEvidence-based Complementary and Alternative Medicine
Volume2017
DOIs
StatePublished - 2017

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Metabolomics
Dyspepsia
Medicine
weikangning
Drug Administration Schedule
Passive Cutaneous Anaphylaxis
Metabolome
Psychological Stress
Energy Metabolism
Multivariate Analysis
Urine
Phenotype
Control Groups
Serum
Research
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning. / Guo, Yu; Li, Zhongfeng; Liu, Xinfeng; Su, Xiaolan; Li, Yijie; Zhu, Jiajie; Song, Yilin; Zhang, Ping; Chen, Jiande D.Z.; Wei, Ruhan; Yang, Jianqin; Wei, Wei.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2017, 4039425, 2017.

Research output: Research - peer-reviewArticle

Guo, Yu ; Li, Zhongfeng ; Liu, Xinfeng ; Su, Xiaolan ; Li, Yijie ; Zhu, Jiajie ; Song, Yilin ; Zhang, Ping ; Chen, Jiande D.Z. ; Wei, Ruhan ; Yang, Jianqin ; Wei, Wei. / 1H NMR-Based Metabonomic Study of Functional Dyspepsia in Stressed Rats Treated with Chinese Medicine Weikangning. In: Evidence-based Complementary and Alternative Medicine. 2017 ; Vol. 2017.
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abstract = "1H NMR-based metabolic profiling combined with multivariate data analysis was used to explore the metabolic phenotype of functional dyspepsia (FD) in stressed rats and evaluate the intervention effects of the Chinese medicine Weikangning (WKN). After a 7-day period of model establishment, a 14-day drug administration schedule was conducted in a WKN-treated group of rats, with the model and normal control groups serving as negative controls. Based on 1H NMR spectra of urine and serum from rats, PCA, PLS-DA, and OPLS-DA were performed to identify changing metabolic profiles. According to the key metabolites determined by OPLS-DA, alterations in energy metabolism, stress-related metabolism, and gut microbiota were found in FD model rats after stress stimulation, and these alterations were restored to normal after WKN administration. This study may provide new insights into the relationship between FD and psychological stress and assist in research into the metabolic mechanisms involved in Chinese medicine.",
author = "Yu Guo and Zhongfeng Li and Xinfeng Liu and Xiaolan Su and Yijie Li and Jiajie Zhu and Yilin Song and Ping Zhang and Chen, {Jiande D.Z.} and Ruhan Wei and Jianqin Yang and Wei Wei",
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AU - Su,Xiaolan

AU - Li,Yijie

AU - Zhu,Jiajie

AU - Song,Yilin

AU - Zhang,Ping

AU - Chen,Jiande D.Z.

AU - Wei,Ruhan

AU - Yang,Jianqin

AU - Wei,Wei

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