18Fluorodeoxyglucose Positron Emission Tomography Imaging of Atherosclerotic Plaque Inflammation Is Highly Reproducible. Implications for Atherosclerosis Therapy Trials

James H.F. Rudd, Kelly S. Myers, Sameer Bansilal, Josef Machac, Ash Rafique, Michael Farkouh, Valentin Fuster, Zahi A. Fayad

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study tested the near-term reproducibility of 18fluorodeoxyglucose positron emission tomography (FDG-PET) imaging of atherosclerosis. Background: It is known that FDG-PET can measure inflammation within the aorta, carotid, and vertebral arteries with histologic validation in humans and animal models of disease. By tracking changes in inflammation over time, PET could be used as a surrogate marker of antiatheroma drug efficacy. However, the short-term variability and reproducibility of the technique are unknown. Methods: We imaged the carotid arteries and aorta in 11 subjects with FDG-PET/computed tomography twice, 14 days apart. We assessed interobserver and intraobserver agreement and interscan variability. Results: Interscan plaque FDG variability over 2 weeks was very low; intraclass correlation coefficients (ICC) ranged between 0.79 and 0.92. Interobserver agreement was high across all territories imaged except aortic arch (ICC values from 0.90 to 0.97, arch 0.71). Intraobserver agreement was high, with ICC values between 0.93 and 0.98. Conclusions: Spontaneous change in plaque FDG uptake is low over 2 weeks, with favorable inter- and intraobserver agreement. Power calculations suggest that drug studies using FDG-PET imaging would require few subjects compared with other imaging modalities. This study strengthens the case for FDG-PET as a noninvasive plaque imaging technique.

Original languageEnglish (US)
Pages (from-to)892-896
Number of pages5
JournalJournal of the American College of Cardiology
Volume50
Issue number9
DOIs
StatePublished - Aug 28 2007
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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