[18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase I expression in the primary tumor

L. Hooft, A. A M Van Der Veldt, P. J. Van Diest, O. S. Hoekstra, J. Berkhof, G. J J Teule, C. F M Molthoff

Research output: Contribution to journalArticle

Abstract

Patients suspected of recurrent differentiated thyroid cancer (DTC) may require "blind" 131I therapy, with the disadvantage of unpredictable efficacy and toxicity. Alternatively, positron emission tomography (PET) with [18F]fluorodeoxyglucose (18FDG) can document the recurrence, thereby rationalizing therapeutic options. This study compared 18FDG uptake in vivo with biomarkers expected to be involved in the underlying biological mechanisms. Additionally, we investigated whether such features were present in the primary tumors. Preoperatively, 19 patients with recurrent DTC underwent PET. 18FDG uptake was compared with histological and immunohistochemical features in surgical specimens of recurrent and primary tumor. Thirteen of 19 recurrences were positive at PET, and 18FDG uptake was associated with the expression of hexokinase type I (HK I; P = 0.011). All lesions with HK I overexpression were positive on 18FDG PET. HK I expression in the original primary tumor and the metastases was similar in 82% (p = 0.648; P = 0.005). In suspected recurrent thyroid cancer, stratification for 18FDG PET may benefit from pretest immunohistochemical analysis of HK I of the primary tumor, as HK I negativity indicates a low likelihood of PET positivity.

Original languageEnglish (US)
Pages (from-to)328-334
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume90
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Hooft, L., Van Der Veldt, A. A. M., Van Diest, P. J., Hoekstra, O. S., Berkhof, J., Teule, G. J. J., & Molthoff, C. F. M. (2005). [18F]fluorodeoxyglucose uptake in recurrent thyroid cancer is related to hexokinase I expression in the primary tumor. Journal of Clinical Endocrinology and Metabolism, 90(1), 328-334. https://doi.org/10.1210/jc.2004-0779