18F-FDG PET/CT and melanoma: Staging, immune modulation and mutation-targeted therapy assessment, and prognosis

Powell Perng, Charles Marcus, Rathan M. Subramaniam

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. Monoclonal antibodies that target the programmed cell death 1 (PD-1) immune checkpoint protein and its associated ligands, PD-L1 and PD-L2, and targeted inhibitors of mutated signal transduction molecules such as BRAF inhibitors show immense promise in treating patients with melanoma. We discuss the use of 18F-FDG PET/CT for assessing therapy effectiveness, staging advanced disease, and determining prognosis of patients with melanoma. CONCLUSION. FDG PET/CT is useful in staging disease, assessing therapy, and determining prognosis in patients with melanoma.

Original languageEnglish (US)
Pages (from-to)259-270
Number of pages12
JournalAmerican Journal of Roentgenology
Volume205
Issue number2
DOIs
StatePublished - Aug 1 2015

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Fluorodeoxyglucose F18
Melanoma
Mutation
Signal Transduction
Cell Death
Therapeutics
Monoclonal Antibodies
Ligands
Proteins

Keywords

  • FDG PET/CT
  • Immune modulation therapy
  • Melanoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

18F-FDG PET/CT and melanoma : Staging, immune modulation and mutation-targeted therapy assessment, and prognosis. / Perng, Powell; Marcus, Charles; Subramaniam, Rathan M.

In: American Journal of Roentgenology, Vol. 205, No. 2, 01.08.2015, p. 259-270.

Research output: Contribution to journalArticle

Perng, Powell ; Marcus, Charles ; Subramaniam, Rathan M. / 18F-FDG PET/CT and melanoma : Staging, immune modulation and mutation-targeted therapy assessment, and prognosis. In: American Journal of Roentgenology. 2015 ; Vol. 205, No. 2. pp. 259-270.
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